Effects of formulation on the bioavailability of lutein and zeaxanthin: a randomized, double-blind, cross-over, comparative, single-dose study in healthy subjects.
Purpose: Lutein and zeaxanthin are macular pigments with a protective function in the retina. These xanthophylls must be obtained from the diet or added to foods or supplements via easy-to-use, stable formulations. The technique employed to produce these formulations may affect the bioavailability o...
| Publicado en: | European Journal of Nutrition Vol. 52; no. 4; pp. 1381 - 1392 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104173867&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104173867 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Jun2013 vid: 52 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104173867 87784328 10.1007/s00394-012-0447-9 NLM23052623 104173867 ppf: 1381 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Effects of formulation on the bioavailability of lutein and zeaxanthin: a randomized, double-blind, cross-over, comparative, single-dose study in healthy subjects. aug: au: Evans, Malkanthi Beck, Mareike Elliott, James Etheve, Stephane Roberts, Richard Schalch, Wolfgang affil: KGK Synergize, London Canada sug: subj: Biological Availability Lutein Blood Zeaxanthin Blood Human Random Sample Double-Blind Studies Crossover Design Comparative Studies Male Female Adult Middle Age Aged Descriptive Statistics Data Analysis Software Funding Source Repeated Measures Analysis of Variance Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: Lutein and zeaxanthin are macular pigments with a protective function in the retina. These xanthophylls must be obtained from the diet or added to foods or supplements via easy-to-use, stable formulations. The technique employed to produce these formulations may affect the bioavailability of the xanthophylls. Methods: Forty-eight healthy volunteers were randomized into this double-blind, cross-over study investigating the plasma kinetics of lutein provided as two different beadlet formulations. Subjects ( n = 48) received a single dose of 20 mg of lutein as either a starch-matrix ('SMB', FloraGLO Lutein 5 %) or as a cross-linked alginate-matrix beadlet ('AMB', Lyc-O-Lutein 20 %) formulation. Plasma concentrations of lutein and zeaxanthin were measured at 0, 1, 3, 6, 9, 12, 14, 24, 26, 28, 32, 36, 48, 72, 168, and 672 h. Results: The mean plasma AUC, AUC, and C for total lutein and zeaxanthin and their all- E-isomers were significantly increased ( p < 0.001) from pre-dose concentrations in response to SMB and AMB. There was no difference in lutein T between the two test articles. However, by 14 h post-dose, total plasma lutein increased by 7 % with AMB and by 126 % with SMB. Total lutein AUC and AUC were 1.8-fold and 1.3-fold higher, respectively, for SMB compared to AMB. Both formulations were well tolerated by subjects in this study. Conclusion: These findings confirm that the bioavailability of lutein and zeaxanthin critically depends on the formulation used and document a superiority of the starch-based over the alginate-based product in this study. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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