Antihypercholesterolemic Effect of Macrotyloma uniflorum (Lam.) Verdc (Fabaceae) Extract on High-Fat Diet-Induced Hypercholesterolemia in Sprague-Dawley Rats.
Objective: The present study evaluated the antihypercholesterolemic effect of Macrotyloma uniflorum (Lam.) Verdc extract by examining its effects on food consumption, weight gain, serum lipid profile, serum glutamate oxaloacetate transamianse (SGOT), serum glutamate pyruvate transaminase (SGPT), and...
| Publicado en: | Journal of Dietary Supplements Vol. 10; no. 2; pp. 116 - 129 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jun2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104175124&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104175124 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19390211 2Y62 jtl: Journal of Dietary Supplements issn: 19390211 maglogo: N pubinfo: dt: Jun2013 vid: 10 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104175124 87915459 10.3109/19390211.2013.790334 NLM23725525 104175124 ppf: 116 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Antihypercholesterolemic Effect of Macrotyloma uniflorum (Lam.) Verdc (Fabaceae) Extract on High-Fat Diet-Induced Hypercholesterolemia in Sprague-Dawley Rats. aug: au: Kumar, D. Sathis Prashanthi, G. Avasarala, Harani Banji, David affil: Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh, India sug: subj: Hypercholesterolemia Therapy Obesity Prevention and Control Plant Extracts Administration and Dosage Animal Studies Rats Dietary Fats Cholesterol Blood Alanine Aminotransferase Blood Aspartate Aminotransferase Lipids Analysis Analysis of Variance Descriptive Statistics Data Analysis Software Dose-Response Relationship Weight Gain Evaluation Adipose Tissue Analysis ab: Objective: The present study evaluated the antihypercholesterolemic effect of Macrotyloma uniflorum (Lam.) Verdc extract by examining its effects on food consumption, weight gain, serum lipid profile, serum glutamate oxaloacetate transamianse (SGOT), serum glutamate pyruvate transaminase (SGPT), and body fat in rats. Methods: Animals were fed with experimental high-fat diets (HFD) that contain 10% lard plus, 5% corn oil. Food intake and body weight were measured. Serum samples were analyzed for the estimation of lipid profiles and other biochemical parameters by using kits. Results: The consumption of ethanol and water extract of experimental plant for 5 weeks caused the decrease in total cholesterol (TC), triglycerides, low-density lipoprotein (LDL), very low density lipoprotein (VLDL) SGOT and SGPT significantly ( p < .01), and increase in high-density lipoprotein (HDL) significantly ( p < .01). The rat group fed with HFD has shown higher serum TC, TG, LDL, VLDL, SGOT, SGPT, and lower HDL than in the normal control group ( p < .01). Fecal excretion of cholesterol in the ethanol extract-treated groups was significantly higher than those treated with water extract. Body weight in the water extract-treated groups was significantly lower than that in the ethanol extract-treated groups. Conclusion: This study demonstrated that M. uniflorum (Lam.) Verdc extracts have strong activities against hypercholesterolemia and obesity suggesting a potential usefulness of M. uniflorum (Lam.) Verdc extracts as functional ingredients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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