Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds.
Chronic wounds that fail to heal are a common complication of diabetes mellitus and the most common precipitating reason for nontraumatic lower limb amputation. Unfortunately, the bacterial species that cause these infections are becoming more resistant to antibiotics, making them increasingly diffi...
| Published in: | Wound Repair & Regeneration Vol. 21; no. 4; pp. 595 - 604 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Jul/Aug2013
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104187090&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104187090 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Jul/Aug2013 vid: 21 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104187090 88800276 10.1111/wrr.12056 NLM23755910 104187090 ppf: 595 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds. aug: au: Mendes, João J. Leandro, Clara Corte-Real, Sofia Barbosa, Raquel Cavaco-Silva, Patrícia Melo-Cristino, José Górski, Andrzej Garcia, Miguel affil: TechnoPhage, S.A.; Internal Medicine Department, Santa Marta's Hospital / Central Lisbon Hospital Center, Lisbon sug: subj: Wound Healing Diabetic Foot Therapy Arboviruses Wounds, Chronic Animal Studies Swine Models, Biological Funding Source Rats Descriptive Statistics T-Tests Data Analysis Software ab: Chronic wounds that fail to heal are a common complication of diabetes mellitus and the most common precipitating reason for nontraumatic lower limb amputation. Unfortunately, the bacterial species that cause these infections are becoming more resistant to antibiotics, making them increasingly difficult to treat. We assessed the feasibility of combating chronic bacterial infections with a topically delivered bacteriophage cocktail in two animal models of diabetes mellitus. Microbiological, planimetric, and histological parameters were compared in debrided infected wounds with or without topical bacteriophage treatment. We determined that bacteriophage treatment effectively decreased bacterial colony counts and improved wound healing, as indicated by smaller epithelial and dermal gaps, in Staphylococcus aureus and Pseudomonas aeruginosa infections but was not as effective against Acinetobacter baumannii. Although the improvements were more significant in the rodent model than in the porcine model, our results suggest that topically administered bacteriophage treatment may be effective in resolving chronic infections, especially when applied in conjunction with wound debridement. These findings have important implications for the feasibility of using topical antimicrobial therapies to safely treat chronic infections in diabetes mellitus patients. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|