Methamphetamine alters blood brain barrier protein expression in mice, facilitating central nervous system infection by neurotropic Cryptococcus neoformans.
Methamphetamine (METH) is a drug of abuse that is a potent and highly addictive central nervous system (CNS) stimulant. The blood brain barrier (BBB) is a unique interface that in part functions to prevent microbial invasion of the CNS. The effects of METH on brain vasculature have not been studied...
| Published in: | Journal of Infectious Diseases Vol. 208; no. 4; pp. 699 - 705 |
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| Main Authors: | , , , , |
| Format: | research Journal Article |
| Published: |
Oxford University Press / USA
Aug2013
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104197683&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104197683 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00221899 1YU jtl: Journal of Infectious Diseases issn: 00221899 maglogo: N pubinfo: dt: Aug2013 vid: 208 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 104197683 NLM23532099 2012199945 10.1093/infdis/jit117 NLM23532099 PMC3719895 104197683 ppf: 699 ppct: 6 formats: tig: atl: Methamphetamine alters blood brain barrier protein expression in mice, facilitating central nervous system infection by neurotropic Cryptococcus neoformans. aug: au: Eugenin, Eliseo A Greco, Jade M Frases, Susana Nosanchuk, Joshua D Martinez, Luis R affil: Public Health Research Institute. sug: subj: Blood-Brain Barrier Blood-Brain Barrier Drug Effects Cryptococcus Immunology Immunosuppressive Agents Adverse Effects Meningitis, Cryptococcal Immunology Methamphetamine Adverse Effects Proteins Drug Effects Animal Studies Brain Microbiology Cell Adhesion Molecules Central Nervous System Stimulants Adverse Effects Female Meningitis, Cryptococcal Mortality Mice Survival Analysis Female ab: Methamphetamine (METH) is a drug of abuse that is a potent and highly addictive central nervous system (CNS) stimulant. The blood brain barrier (BBB) is a unique interface that in part functions to prevent microbial invasion of the CNS. The effects of METH on brain vasculature have not been studied extensively. We hypothesized that METH alters the BBB integrity, increasing susceptibility to CNS infection. Using a murine model of METH administration, we demonstrated that METH alters BBB integrity and modifies the expression of tight junction and adhesion molecules. Additionally, we showed that BBB disruption accelerates transmigration of the neurotropic fungus Cryptococcus neoformans into the brain parenchyma after systemic infection. Furthermore, METH-treated mice displayed increased mortality as compared to untreated animals. Our findings provide novel evidence of the impact of METH abuse on the integrity of the cells that comprise the BBB and protect the brain from infection. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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