No detection of Helicobacter pylori in atherosclerotic plaques in end stage renal disease patients undergoing kidney transplantation.
Chronic infection known to be a predisposing factor for the development of atherosclerosis. Several studies have found a possible role of Helicobacter pylori in the pathogenesis of atherosclerosis. The aim of this study was to investigate the presence of H. pylori in atherosclerotic plaques in iliac...
| Publicado en: | Indian Journal of Nephrology Vol. 23; no. 4; pp. 259 - 264 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Scientific Scholar LLC
Jul/Aug2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104200926&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104200926 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09714065 1CQK jtl: Indian Journal of Nephrology issn: 09714065 maglogo: N pubinfo: dt: Jul/Aug2013 vid: 23 iid: 4 pid: 56013 pub: Scientific Scholar LLC place: Pittsford, New York artinfo: ui: 104200926 89239571 10.4103/0971-4065.114483 NLM23960340 104200926 ppf: 259 ppct: 5 formats: tig: atl: No detection of Helicobacter pylori in atherosclerotic plaques in end stage renal disease patients undergoing kidney transplantation. aug: au: Ahmadnia, H. Vossoughinia, H. Mansourian, E. Gaffarzadegan, K. affil: Department of Urology, Mashhad University of Medical Sciences, Mashhad, Iran sug: subj: Kidney Transplantation Arteriosclerosis Helicobacter Infections Human Iran Academic Medical Centers Endoscopy Utilization Biopsy Utilization Polymerase Chain Reaction Utilization Adult Middle Age Mann-Whitney U Test Fisher's Exact Test Logistic Regression Surgical Equipment and Supplies Male Female Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Chronic infection known to be a predisposing factor for the development of atherosclerosis. Several studies have found a possible role of Helicobacter pylori in the pathogenesis of atherosclerosis. The aim of this study was to investigate the presence of H. pylori in atherosclerotic plaques in iliac arteries in 25 end stage renal disease (ESRD) patients undergoing kidney transplantation. Esophagogastroduodenoscopy was performed in all patients before transplantation. Biopsy specimens obtained from gastric antrum were sent for pathologic evaluation. Gastric H. pylori infection was confirmed by microscopic assessment and rapid urease test. Arterial specimens were obtained from iliac arteries during kidney transplantation. Presence of H. pylori DNA in atherosclerotic plaques and healthy vessel samples was evaluated by the polymerase chain reaction (PCR). The mean age of patients was 44.1 ± 22.6 years. Risk factors in patients with atherosclerosis were hypertension (68%), diabetes mellitus (20%), hyperlipidemia (20%), positive family history (16%). Atherosclerotic plaques were found in 21 (84%) patients. PCR analysis did not detect H. pylori in any case. There was a significant relationship of atherosclerosis with hypertension (P = 0.006) but not with diabetes mellitus and hyperlipidemia (P = 0.5). There was no significant relationship between atherosclerosis and gastric H. pylori infection (P = 0.6). This study revealed no association between the presence of H. pylori as a pathogen of vessel walls and atherosclerosis in ESRD. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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