Neurocognitive and behavioral outcomes in Latino childhood cancer survivors.
Background: Children with brain tumors and leukemia are at risk for neurocognitive and behavioral late effects due to central nervous system-directed therapies. Few studies have examined these outcomes in ethnic minority samples, despite speculation that socio-demographic factors may increase vulner...
| Publicado en: | Pediatric Blood & Cancer Vol. 60; no. 10; pp. 1696 - 1703 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104205850&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104205850 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15455009 1XL2 jtl: Pediatric Blood & Cancer issn: 15455009 maglogo: Y pubinfo: dt: Oct2013 vid: 60 iid: 10 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104205850 NLM23733619 2012219232 10.1002/pbc.24608 NLM23733619 PMC3776597 104205850 ppf: 1696 ppct: 7 formats: tig: atl: Neurocognitive and behavioral outcomes in Latino childhood cancer survivors. aug: au: Patel, Sunita K Lo, Tracy T Y Dennis, Jessica M Bhatia, Smita affil: Department of Population Sciences, City of Hope Medical Center & Beckman Research Institute, Duarte, California; Department of Pediatrics, City of Hope Medical Center & Beckman Research Institute, Duarte, California; Department of Supportive Care Medicine, City of Hope Medical Center & Beckman Research Institute, Duarte, California. sug: subj: Behavior Epidemiology Brain Neoplasms Hispanic Americans Learning Learning Disorders Epidemiology Leukemia Psychomotor Agitation Epidemiology Survivors Adolescence Adult Behavior Child Female Human Learning Disorders Therapy Male Psychomotor Agitation Therapy Quality of Life Scales Socioeconomic Factors Funding Source Questionnaires Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years Female Male ab: Background: Children with brain tumors and leukemia are at risk for neurocognitive and behavioral late effects due to central nervous system-directed therapies. Few studies have examined these outcomes in ethnic minority samples, despite speculation that socio-demographic factors may increase vulnerability for adverse neurobehavioral outcomes. We evaluated the neurocognitive and behavioral outcomes and their impact on the health-related quality of life in survivors of childhood cancer drawn from Latino families in the Los Angeles region.Procedure: Using culturally-relevant recruitment strategies, 73 predominantly Spanish-speaking parents of pediatric brain tumor or leukemia survivors completed standardized questionnaires, including the Conners parent-report and the Bidimensional Acculturation Scales. Clinical and socio-demographic factors influencing the development of neurocognitive and behavioral dysfunction were examined.Results: Approximately 50% of the children placed at or above the "elevated" level for difficulties with attention, school-based learning, and peer relations. Younger age at diagnosis significantly predicted dysfunction in inattention, learning problems, and hyperactivity/impulsivity. Children whose parents were less adherent to the non-Hispanic white culture were more likely to have problems with peer relations and executive functioning. HRQL was significantly lower in survivors with neurocognitive and behavioral dysfunction relative to those with normal range scores on the Conners scale.Conclusions: In addition to the child's age at diagnosis, acculturation appears to predict select neurocognitive and behavioral outcomes in this socio-demographically homogeneous sample of Latino families. Further research is needed to understand the interaction of ethnic and cultural factors with therapeutic exposures in determining the adverse neurobehavioral outcomes, so as to optimally design interventions. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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