Diagnostic precision of retinal nerve fiber layer and macular thickness asymmetry parameters for identifying early primary open-angle glaucoma.
Purpose: To evaluate the diagnostic capabilities of intereye and intraeye differences in retinal nerve fiber layer (RNFL) thickness and macular thickness for identifying early primary open-angle glaucoma (POAG).Design: Prospective, cross-sectional cohort study.Methods: All subjects were enrolled fro...
| Publicado en: | American Journal of Ophthalmology Vol. 156; no. 3; pp. 567 - 568 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Sep2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104212293&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104212293 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00029394 1WV jtl: American Journal of Ophthalmology issn: 00029394 maglogo: N pubinfo: dt: Sep2013 vid: 156 iid: 3 pid: 82545 pub: Elsevier B.V. place: Philadelphia, Pennsylvania artinfo: ui: 104212293 NLM23810475 2012229110 10.1016/j.ajo.2013.04.037 NLM23810475 104212293 ppf: 567 ppct: 1 formats: tig: atl: Diagnostic precision of retinal nerve fiber layer and macular thickness asymmetry parameters for identifying early primary open-angle glaucoma. aug: au: Sullivan-Mee, Michael Ruegg, Claudia C Pensyl, Denise Halverson, Kathy Qualls, Clifford affil: New Mexico Veterans Administration Health Care System, Albuquerque, New Mexico. Electronic address: Michael.Sullivan-Mee@va.gov. sug: subj: Glaucoma Diagnosis Retina Pathology Nerve Fibers Pathology Optic Nerve Pathology Optic Nerve Diseases Diagnosis Aged Cross Sectional Studies Female Human Intraocular Pressure Male Prospective Studies ROC Curve Reproducibility of Results Sensitivity and Specificity Tomography Vision Disorders Diagnosis Perimetry Visual Fields Aged: 65+ years Female Male ab: Purpose: To evaluate the diagnostic capabilities of intereye and intraeye differences in retinal nerve fiber layer (RNFL) thickness and macular thickness for identifying early primary open-angle glaucoma (POAG).Design: Prospective, cross-sectional cohort study.Methods: All subjects were enrolled from an ongoing institutional glaucoma study. We used spectral-domain optical coherence tomography (Spectralis; Heidelberg Engineering) to obtain macular thickness (posterior pole asymmetry scan) and RNFL thickness (circumpapillary scan) in both eyes of 50 early POAG and 50 control subjects. Early POAG subjects had glaucomatous optic neuropathy with mild, reproducible visual field loss in at least 1 eye, and control subjects had normal intraocular pressures, visual fields, and optic nerves. We recorded total, superior, and inferior RNFL and macular thicknesses and then calculated intereye and intraeye differences (asymmetry parameters). Statistical evaluation included receiver operating characteristic and multivariate logistic regression analyses.Results: Intereye macular thickness asymmetry had the highest diagnostic sensitivity (88% at 80% specificity; 83% at 95% specificity), followed by total RNFL thickness (88% at 80% specificity; 75% at 95% specificity). Parameters with the largest areas under the receiver operating characteristic curves were: total RNFL thickness (0.937), intereye RNFL asymmetry (0.921), intereye macular thickness asymmetry (0.913), inferior RNFL thickness (0.905), superior RNFL thickness (0.887), intereye inferior macular thickness asymmetry (0.872), and intraeye macular thickness asymmetry (0.860). These 7 values were not significantly different. In multivariate logistic regression analyses, intraeye macular thickness asymmetry, intereye macular thickness asymmetry, intereye RNFL thickness asymmetry, and total RNFL thickness were related independently to early POAG.Conclusions: Structural asymmetry parameters performed well, identifying early POAG as well as RNFL thickness. Further study is indicated to validate these results. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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