Absence of Airway Secretion Accumulation Predicts Tolerance of Noninvasive Ventilation in Subjects With Amyotrophic Lateral Sclerosis.
OBJECTIVE: To assess factors that predict good tolerance of noninvasive ventilation (NIV), in order to improve survival and quality of life in subjects with amyotrophic lateral sclerosis. METHODS: We conducted a prospective study in subjects with amyotrophic lateral sclerosis and requiring NIV. The...
| Published in: | Respiratory Care Vol. 58; no. 9; pp. 1424 - 1433 |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Mary Ann Liebert, Inc.
Sep2013
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104215072&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104215072 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Sep2013 vid: 58 iid: 9 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 104215072 89853127 10.4187/respcare.02103 NLM23322888 104215072 ppf: 1424 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Absence of Airway Secretion Accumulation Predicts Tolerance of Noninvasive Ventilation in Subjects With Amyotrophic Lateral Sclerosis. aug: au: Vandenberghe, Nadia Vallet, Anne-Evelyne Petitjean, Thierry Le Cam, Pierre Peysson, Stéphane Guérin, Claude Dailler, Frédéric Jay, Sylvie Cadiergue, Vincent Bouhour, Françoise Court-Fortune, Isabelle Camdessanche, Jean-Philippe Antoine, Jean-Christophe Philit, François Beuret, Pascal Bin-Dorel, Sylvie Vial, Christophe Broussolle, Emmanuel affil: Service d'Electroneuromyographie et Service de Neurologie C, Centre Sclérose Latérale Amyotrophique de Lyon, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France sug: subj: Noninvasive Procedures Utilization Amyotrophic Lateral Sclerosis Prognosis Human Descriptive Research Odds Ratio Confidence Intervals Descriptive Statistics Data Analysis Software Fisher's Exact Test Mann-Whitney U Test Chi Square Test Step-Wise Multiple Regression Goodness of Fit Chi Square Test Male Female Middle Age Aged Funding Source Middle Aged: 45-64 years Aged: 65+ years Male Female ab: OBJECTIVE: To assess factors that predict good tolerance of noninvasive ventilation (NIV), in order to improve survival and quality of life in subjects with amyotrophic lateral sclerosis. METHODS: We conducted a prospective study in subjects with amyotrophic lateral sclerosis and requiring NIV. The primary end point was NIV tolerance at 1 month. Subjects, several of whom failed to complete the study, were classified as 'tolerant' or 'poorly tolerant,' according to the number of hours of NIV use (more or less than 4 h per night, respectively). RESULTS: Eighty-one subjects, 73 of whom also attended the 1-month follow-up visit, participated over 34 months. NIV tolerance after the first day of utilization predicted tolerance at 1 month (77.6% and 75.3% of subjects, respectively). Multivariate analysis disclosed 3 factors predicting good NIV tolerance: absence of airway secretions accumulation prior to NIV onset (odds ratio 11.5); normal bulbar function at initiation of NIV (odds ratio 8.5); and older age (weakly significant, odds ratio 1.1). CONCLUSION: Our study reveals 3 factors that are predictive of good NIV tolerance, in particular the absence of airway secretion accumulation, which should prompt NIV initiation before its appearance. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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