Low rate of recurrence of Helicobacter pylori infection in spite of high clarithromycin resistance in Pakistan.
Background: The aim was to investigate the reinfection rate of H. pylori during a follow-up period of 12 months in adults who had undergone eradication therapy.Methods: One hundred-twenty patients; 116 with gastritis, 3 with duodenal ulcer and 1 gastric ulcer, were studied. Their mean age was 41±13...
| Publicado en: | BMC Gastroenterology Vol. 13; no. 1; pp. 33 - 34 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104225410&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104225410 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1471230X 1CHO jtl: BMC Gastroenterology issn: 1471230X maglogo: N pubinfo: dt: 2013 vid: 13 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 104225410 104225410 NLM23433429 2012261278 10.1186/1471-230X-13-33 NLM23433429 PMC3608237 104225410 ppf: 33 ppct: 1 formats: tig: atl: Low rate of recurrence of Helicobacter pylori infection in spite of high clarithromycin resistance in Pakistan. aug: au: Yakoob, Javed Abid, Shahab Jafri, Wasim Abbas, Zaigham Mumtaz, Khalid Hamid, Saeed Ahmed, Rashida affil: Department of Medicine, Aga Khan University, Stadium Road, Karachi, 74800, Pakistan. shahab.abid@aku.edu. sug: subj: Antibiotics Therapeutic Use Clarithromycin Therapeutic Use Drug Resistance, Microbial Helicobacter Infections Drug Therapy Helicobacter Infections Epidemiology Helicobacter Pylori Adolescence Adult Aged Amoxicillin Therapeutic Use Female Prospective Studies Gastritis Microbiology Human Male Middle Age Pakistan Peptic Ulcer Microbiology Prevalence Recurrence Treatment Outcomes Young Adult Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Background: The aim was to investigate the reinfection rate of H. pylori during a follow-up period of 12 months in adults who had undergone eradication therapy.Methods: One hundred-twenty patients; 116 with gastritis, 3 with duodenal ulcer and 1 gastric ulcer, were studied. Their mean age was 41±13 years (range 18-77) and male: female ratio of 2:1. H. pylori were cultured and antibiotic sensitivity was determined by Epsilometer test (E-test) for clarithromycin (CLR) and amoxicillin (AMX). Primers of urease C gene of H. pylori and Sau-3 and Hha I restriction enzymes were used for polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). 14C urea breath test (14C-UBT) was performed 4 weeks after the eradication therapy. The successfully treated patients were observed for 12 months with 14C-UBT to assess H. pylori status. If 14C-UBT was negative, it was repeated after every 12 weeks. If 14C-UBT was positive, endoscopy was repeated with biopsies.Result: The eradication therapy was successful in 102(85%) patients. Out of forty-seven H. pylori isolates cultured, clarithromycin sensitivity was present in 30(64%) and amoxicillin in 45(98%), respectively. Follow-up 14C-urea breath tests of all 102 patients who eradicated H. pylori remained negative up to 9 months. However, in 6 patients, the 14C-UBT confirmed recurrence at 12 months. The recurrence rate was 6%.Conclusion: A low rate of recurrence of H. pylori infection was found in patients with dyspeptic symptoms. H. pylori isolates demonstrated a high invitro clarithromycin resistance. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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