The Relative Benefits of Tamoxifen in Older Women with T1 Early-Stage Breast Cancer Treated with Breast-Conserving Surgery and Radiation Therapy.
Small, hormone receptor-positive breast carcinomas in older women are associated with low local recurrence rates. The relative benefits of adjuvant hormonal therapy remain unclear in elderly women with small, node-negative breast cancer after breast-conserving surgery and adjuvant radiation therapy....
| Publicado en: | Breast Journal Vol. 19; no. 5; pp. 490 - 496 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Sep/Oct2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104233317&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104233317 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1075122X ET6 jtl: Breast Journal issn: 1075122X maglogo: Y pubinfo: dt: Sep/Oct2013 vid: 19 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104233317 90468317 10.1111/tbj.12150 NLM23800027 104233317 ppf: 490 ppct: 6 formats: fmt: @attributes: type: P tig: atl: The Relative Benefits of Tamoxifen in Older Women with T1 Early-Stage Breast Cancer Treated with Breast-Conserving Surgery and Radiation Therapy. aug: au: Khan, Atif J. Parikh, Rahul R. Neboori, Hanmanth J. Goyal, Sharad Haffty, Bruce G. Moran, Meena S. affil: Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ/Robert Wood Johnson Medical School sug: subj: Breast Neoplasms Drug Therapy Breast Neoplasms Radiotherapy Breast Neoplasms Surgery Tamoxifen Therapeutic Use Neoplasm Staging Human Aged Aged, 80 and Over Female Descriptive Statistics P-Value Chi Square Test Kaplan-Meier Estimator T-Tests Cox Proportional Hazards Model Data Analysis, Statistical Data Analysis Software Exploratory Research Survival Analysis Confidence Intervals Multivariate Analysis Middle Age Retrospective Design Record Review Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female ab: Small, hormone receptor-positive breast carcinomas in older women are associated with low local recurrence rates. The relative benefits of adjuvant hormonal therapy remain unclear in elderly women with small, node-negative breast cancer after breast-conserving surgery and adjuvant radiation therapy. From our institutional data base, 224 patients ≥65 years of age with T1N0M0 breast cancer treated with BCS+ RT were identified. Of these, 102 patients (45.5%) received tamoxifen ( TAM) and 122 patients (54.5%) did not (no- TAM). The median follow-up time was 62.6 months. The 10-year local relapse-free survival ( LRFS) was 98% in both the TAM and no- TAM cohorts (p = 0.58); the 10-year DMFS was 83% TAM vs. 89% no- TAM (p = 0.91). There was no difference in 10-year contralateral breast relapse or overall survival ( OS) between the two cohorts. In univariate and multivariate analysis, use of TAM was not associated with LRFS, distant metastases-free survival ( DMFS), OS, or a reduction in contralateral breast cancers when compared with the no- TAM cohort. In this large cohort of T1N0 elderly breast cancer patients treated with CS+ RT, the use of TAM did not appear to decrease ipsilateral breast relapse, contralateral breast relapse, distant metastasis, or OS. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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