Additional corpus biopsy enhances the detection of Helicobacter pylori infection in a background of gastritis with atrophy.
Background: The best sites for biopsy-based tests to evaluate H. pylori infection in gastritis with atrophy are not well known. This study aimed to evaluate the site and sensitivity of biopsy-based tests in terms of degree of gastritis with atrophy.Methods: One hundred and sixty-four (164) uninvesti...
| Published in: | BMC Gastroenterology Vol. 12; no. 1; pp. 182 - 183 |
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| Main Authors: | , , , , |
| Format: | research Journal Article |
| Published: |
BioMed Central
2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104237351&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104237351 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1471230X 1CHO jtl: BMC Gastroenterology issn: 1471230X maglogo: N pubinfo: dt: 2012 vid: 12 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 104237351 104237351 NLM23272897 2012014218 10.1186/1471-230X-12-182 NLM23272897 PMC3573986 104237351 ppf: 182 ppct: 1 formats: tig: atl: Additional corpus biopsy enhances the detection of Helicobacter pylori infection in a background of gastritis with atrophy. aug: au: Lan, Hung-Chieh Chen, Tseng-Shing Li, Anna Fen-Yau Chang, Full-Young Lin, Han-Chieh affil: Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University, #201 Shih-Pai Road, Section 2, Taipei, Taiwan, ROC. tschen@vghtpe.gov.tw. sug: subj: Gastritis Pathology Helicobacter Infections Pathology Helicobacter Pylori Stomach Pathology Biopsy Chi Square Test Female Gastric Mucosa Gastric Mucosa Microbiology Gastric Mucosa Pathology Helicobacter Infections Helicobacter Infections Microbiology Human Male Predictive Value of Tests Pyloric Antrum Pathology Stomach Stomach Microbiology Urease Metabolism Female Male ab: Background: The best sites for biopsy-based tests to evaluate H. pylori infection in gastritis with atrophy are not well known. This study aimed to evaluate the site and sensitivity of biopsy-based tests in terms of degree of gastritis with atrophy.Methods: One hundred and sixty-four (164) uninvestigated dyspepsia patients were enrolled. Biopsy-based tests (i.e., culture, histology Giemsa stain and rapid urease test) and non-invasive tests (anti-H. pylori IgG) were performed. The gold standard of H. pylori infection was defined according to previous criteria. The sensitivity, specificity, positive predictive rate and negative predictive rate of biopsy-based tests at the gastric antrum and body were calculated in terms of degree of gastritis with atrophy.Results: The prevalence rate of H. pylori infection in the 164 patients was 63.4%. Gastritis with atrophy was significantly higher at the antrum than at the body (76% vs. 31%; p<0.001). The sensitivity of biopsy-based test decreased when the degree of gastritis with atrophy increased regardless of biopsy site (for normal, mild, moderate, and severe gastritis with atrophy, the sensitivity of histology Giemsa stain was 100%, 100%, 88%, and 66%, respectively, and 100%, 97%, 91%, and 66%, respectively, for rapid urease test). In moderate to severe antrum or body gastritis with atrophy, additional corpus biopsy resulted in increased sensitivity to 16.67% compare to single antrum biopsy.Conclusions: In moderate to severe gastritis with atrophy, biopsy-based test should include the corpus for avoiding false negative results. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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