Incomplete clinical manifestation as a risk factor for coronary artery abnormalities in Kawasaki disease: a meta-analysis.
Incomplete Kawasaki disease (KD) comprises a large proportion of the total number of cases. Although it has the potential of delaying diagnosis, it is not conclusive whether an incomplete presentation is a risk factor for coronary artery abnormalities (CAAs). We performed a meta-analysis to establis...
| Publicado en: | European Journal of Pediatrics Vol. 172; no. 3; pp. 343 - 350 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104239634&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104239634 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03406199 CR1 jtl: European Journal of Pediatrics issn: 03406199 maglogo: N pubinfo: dt: Mar2013 vid: 172 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104239634 NLM23229186 2012019818 10.1007/s00431-012-1891-5 NLM23229186 104239634 ppf: 343 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Incomplete clinical manifestation as a risk factor for coronary artery abnormalities in Kawasaki disease: a meta-analysis. aug: au: Ha, Kee-Soo Jang, Giyoung Lee, Junghwa Lee, Kwangchul Hong, Youngsook Son, Changsung Lee, Joowon affil: Department of Pediatrics, Korea University Medical Center Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul, 152-703, Republic of Korea. sug: subj: Heart Defects, Congenital Etiology Mucocutaneous Lymph Node Syndrome Complications Age Factors Asians Heart Defects, Congenital Ethnology Human Meta Analysis Models, Statistical Mucocutaneous Lymph Node Syndrome Diagnosis Mucocutaneous Lymph Node Syndrome Ethnology Odds Ratio Risk Factors White Persons ab: Incomplete Kawasaki disease (KD) comprises a large proportion of the total number of cases. Although it has the potential of delaying diagnosis, it is not conclusive whether an incomplete presentation is a risk factor for coronary artery abnormalities (CAAs). We performed a meta-analysis to establish the risk of CAA in 20 studies including 4,504 cases and 32,519 controls, and the risk of giant aneurysm in two studies including 5,390 cases and 37,648 controls. The pooled results indicated that incomplete KD was associated with an increased risk of CAA [odds ratio (OR) = 1.447, 95 % confidence interval (CI) = 1.158-1.808, p = 0.001]. Subgroup analyses demonstrated higher associations in patients younger than 12 months (OR = 2.023, 95 % CI = 1.252-3.271, p = 0.004), Asians and Indians (OR = 1.57, 95 % CI = 1.234-1.999, p < 0.001 and OR = 7.088, 95 % CI = 1.640-30.631, p = 0.009, respectively). Subgroup analysis according to the period of patient enrollment before and after 2004 showed increased association of incomplete KD with CAA only among studies with patients enrolled after 2004 (OR = 1.969, 95 % CI = 1.240-3.127, p = 0.004). In conclusion, incomplete KD seems to be associated with an increased risk of CAA, and this is more prominent in patients younger than 12 months, Asians and Indians. pubtype: Academic Journal doctype: meta analysis research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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