Population pharmacokinetics and pharmacogenetics of alcohol in Chinese and Indians in Singapore.
What is known and Objective: Interindividual variability in alcohol pharmacokinetics is influenced by a number of factors, including polymorphisms in genes mediating alcohol pharmacology, ethnicity, sex and body size. Several studies have evaluated the population pharmacokinetics of alcohol from bre...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 38; no. 2; pp. 141 - 150 |
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| Autores principales: | , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104244613&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104244613 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Apr2013 vid: 38 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104244613 85922671 10.1111/jcpt.12003 NLM23240771 104244613 ppf: 141 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Population pharmacokinetics and pharmacogenetics of alcohol in Chinese and Indians in Singapore. aug: au: Seng, K. Y. Limenta, L. M. G. Heng, D. Lee, E. J. D. affil: Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore sug: subj: Pharmacogenetics Statistics and Numerical Data Ethanol Pharmacokinetics Human Ethnological Research Male Female Ethnic Groups Descriptive Statistics Data Analysis Software Ethanol Administration and Dosage Breath Tests Genotype Adult Middle Age Confidence Intervals Post Hoc Analysis Funding Source Singapore Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: What is known and Objective: Interindividual variability in alcohol pharmacokinetics is influenced by a number of factors, including polymorphisms in genes mediating alcohol pharmacology, ethnicity, sex and body size. Several studies have evaluated the population pharmacokinetics of alcohol from breath alcohol measures. None of these studies, however, have evaluated ethnicity and alcohol-metabolizing enzyme genotypes as covariates in their population pharmacokinetic modelling. We aimed to develop a population pharmacokinetic model using clinical and genetic factors and to identify covariates that influenced interindividual variability in alcohol clearance and volume of distribution. Methods: Hundred and eighty healthy subjects (90 Chinese and 90 Indians; 45 males and 45 females from each ethnic group) ingested a vodka-orange juice mixture to simulate social drinking. Subjects were genotyped for the ADH1B (Arg48His), ALDH2 (Glu504Lys) and CYP2E1 (c.-1293G>C and c.-1053C>T) polymorphisms. A base pharmacokinetic model was developed using the nonmem software (NONMEM Project Group, University of California, San Francisco, San Francisco, CA, USA) to determine the alcohol clearance and volume of distribution. The model was extended to include covariates that influenced the between-subject variability. Results and Discussion: Body weight and sex significantly influenced absorption rate and volume of distribution of alcohol. Body weight and ADH1B Arg48His polymorphism significantly influenced alcohol clearance. The Michaelis-Menten elimination rate ( Vmax) was decreased by 10% in homozygous ADH1B*1/*1 subjects. Ethnicity was not determined to be a significant covariate in the final population pharmacokinetic model. What is new and Conclusion: Gender and body weight were covariates that contributed most to explaining the observed interindividual alcohol pharmacokinetic variability. Of the four SNPs examined in this study, only ADH1B Arg48His polymorphism had a significant, though modest, effect on the pharmacokinetics of alcohol. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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