Quantitative measurement of ultrasound attenuation and Hepato-Renal Index in Non-Alcoholic Fatty Liver Disease.
Objective: The aim of this study was to non-invasively explore new methods of ultrasound attenuation measurements in livers of patients with Non-Alcoholic-Fatty-Liver-Disease (NAFLD) and to measure the liver tissue elasticity.Material and Method: Sixteen patients with NAFLD, twelve patients with liv...
| Publicado en: | Medical Ultrasonography Vol. 15; no. 1; pp. 16 - 23 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Romanian Society of Ultrasonography in Medicine & Biology
Mar2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104251580&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104251580 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18444172 AX1S jtl: Medical Ultrasonography issn: 18444172 maglogo: N pubinfo: dt: Mar2013 vid: 15 iid: 1 pid: 57537 pub: Romanian Society of Ultrasonography in Medicine & Biology artinfo: ui: 104251580 NLM23486619 2012046811 10.11152/mu.2013.2066.151.hlv1qmu2 NLM23486619 104251580 ppf: 16 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Quantitative measurement of ultrasound attenuation and Hepato-Renal Index in Non-Alcoholic Fatty Liver Disease. aug: au: von Volkmann, Hilde Loland Havre, Roald Flesland Loberg, Else Marit Haaland, Terese Immervoll, Heike Haukeland, John Willy Hausken, Trygve Gilja, Odd Helge von Volkmann, Hilde Løland Løberg, Else Marit affil: Department of Medicine, Haukeland University Hospital, N5021 Bergen, Norway sug: subj: Algorithms Fatty Liver Ultrasonography Image Interpretation, Computer Assisted Methods Kidney Ultrasonography Liver Ultrasonography Adult Female Human Image Enhancement Methods Male Middle Age Reproducibility of Results Sensitivity and Specificity Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objective: The aim of this study was to non-invasively explore new methods of ultrasound attenuation measurements in livers of patients with Non-Alcoholic-Fatty-Liver-Disease (NAFLD) and to measure the liver tissue elasticity.Material and Method: Sixteen patients with NAFLD, twelve patients with liver fibrosis and fifteen healthy subjects were included. Echo Levels (ELs) in dB were measured at 2 and 7 cm depths in the right liver to calculate the attenuation. ELs were measured in liver and right kidney tissue to calculate the Hepato-Renal Index (HRI). This index was calculated both as a difference, HRI-diff; (EL Liver -EL Kidney) and HRI-ratio; (EL Liver / EL Kidney) using built-in software of the ultrasound scanner. Liver tissue elasticity was measured using transient elastography (TE, Fibroscan®). NAFLD and liver fibrosis were confirmed by liver biopsy.Results: We found that HRI- diff was significantly higher in the NAFLD group compared with healthy subjects, 6.2 dB (0.8-11.4) vs.1. 9 dB (0.0-6.1), p=0.012. HRI- ratio was significantly lower between the same two groups, 0.9 dB (0.8-1.02) vs.1.01 dB (0.9-1.12), and p<0.0001. TE, ELs and liver size showed significant differences between NAFLD patients and healthy controls. Between patients with fibrosis and NAFLD the differences were significant for TE, liver size and attenuation. Intra- and interobserver correlation and agreement of ELs were good.Conclusion: Measurements of liver tissue using HR-Indexes, ultrasound attenuation, and tissue elasticity may be useful methods to differentiate objectively between steatosis and healthy and quantify the differences. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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