The epidemiology of intermittent and chronic ataxia in children in Manitoba, Canada.
AIM: To determine the epidemiology of chronic ataxia in children in Manitoba, Canada. METHOD: A retrospective study using multiple sources and disease codes identified children (age 0-16y) with chronic ataxia (>2mo duration or recurrent episodes of ataxia) seen at Winnipeg Children's Hospital from 1...
| Publicado en: | Developmental Medicine & Child Neurology Vol. 55; no. 4; pp. 341 - 348 |
|---|---|
| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104251718&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104251718 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00121622 1VN jtl: Developmental Medicine & Child Neurology issn: 00121622 maglogo: Y pubinfo: dt: Apr2013 vid: 55 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104251718 2012047066 10.1111/dmcn.12081 NLM23398196 104251718 ppf: 341 ppct: 7 formats: tig: atl: The epidemiology of intermittent and chronic ataxia in children in Manitoba, Canada. aug: au: Salman, Michael S Lee, Esther J Tjahjadi, Anindita Chodirker, Bernard N affil: Section of Pediatric Neurology, Department of Pediatrics and Child Health, Children's Hospital, University of Manitoba, Winnipeg, MB. sug: subj: Angelman Syndrome Complications Ataxia Epidemiology Ataxia Etiology Ataxia Telangiectasia Complications Mitochondrial Diseases Complications Adolescence Age of Onset Angelman Syndrome Epidemiology Ataxia Mortality Ataxia Telangiectasia Epidemiology Child Chronic Disease Developmental Disabilities Epidemiology Developmental Disabilities Etiology Disease Progression Female Human Incidence Male Manitoba Mitochondrial Diseases Epidemiology Prevalence Retrospective Design Seizures Epidemiology Seizures Etiology Young Adult Adolescent: 13-18 years Child: 6-12 years Female Male ab: AIM: To determine the epidemiology of chronic ataxia in children in Manitoba, Canada. METHOD: A retrospective study using multiple sources and disease codes identified children (age 0-16y) with chronic ataxia (>2mo duration or recurrent episodes of ataxia) seen at Winnipeg Children's Hospital from 1991 to 2008. Patients with isolated peripheral nerve diseases, vestibular disorders, or brain tumors were excluded. RESULTS: We identified 184 patients (males=females; mean age 15y, SD 7y 8mo) with chronic ataxia. Median age at the presenting symptom onset was 1 year 3 months and at ataxia onset 3 years 1 month. Median duration of follow-up was 6 years 5 months. During the study period, the crude incidence rate was 5.77 in 10 000; the crude prevalence rate was 6.59 in 10 000; and the crude mortality rate 0.446 in 10 000. The most common presenting symptoms were developmental delay, ataxia, or seizures. The most common diagnoses (known in 129) were Angelman syndrome (n=16), ataxia telangiectasia (n=13), mitochondrial disease (n=9), Friedreich ataxia (n=7), stroke (n=7), and familial/genetic episodic ataxia (n=7). INTERPRETATION: Chronic ataxia is a relatively common early-presenting symptom in childhood. A specific diagnosis is possible in 70% of patients after extensive investigations. The mortality rate is relatively low and the disease burden is high with significant comorbidities including developmental delay and epilepsy. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|