A novel functional infrared imaging system coupled with multiparametric computerised analysis for risk assessment of breast cancer.
Objective: We evaluated a functional three-dimensional (3D) infrared imaging system (3DIRI) coupled with multiparametric computer analysis for risk assessment of breast cancer. The technique provides objective risk assessment for the presence of a malignant tumour based on automated parameters deriv...
| Published in: | European Radiology Vol. 23; no. 5; pp. 1191 - 1199 |
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| Main Authors: | , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
May2013
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104269987&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104269987 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2013 vid: 23 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104269987 86879554 NLM23223805 2012081831 10.1007/s00330-012-2724-7 NLM23223805 104269987 ppf: 1191 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A novel functional infrared imaging system coupled with multiparametric computerised analysis for risk assessment of breast cancer. aug: au: Sella, Tamar Sklair-Levy, Miri Cohen, Maya Rozin, Mona Shapiro-Feinberg, Myra Allweis, Tanir M Libson, Eugene Izhaky, David affil: Department of Diagnostic Imaging, Hadassah Hebrew University Medical Center, Jerusalem, Israel, 91120, Tamarse@hadassah.org.il. sug: subj: Breast Neoplasms Diagnosis Breast Neoplasms Epidemiology Diagnostic Imaging Equipment and Supplies Diagnostic Imaging Statistics and Numerical Data Cox Proportional Hazards Model Thermography Equipment and Supplies Thermography Statistics and Numerical Data Adult Aged Aged, 80 and Over Female Human Radiation, Non-Ionizing Israel Middle Age Prevalence Prospective Studies Reproducibility of Results Risk Assessment Sensitivity and Specificity Single-Blind Studies Thermography Methods Young Adult Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female ab: Objective: We evaluated a functional three-dimensional (3D) infrared imaging system (3DIRI) coupled with multiparametric computer analysis for risk assessment of breast cancer. The technique provides objective risk assessment for the presence of a malignant tumour based on automated parameters derived from a clinically known training set.Methods: Following institutional review board approval, we recruited 434 women for this prospective multicentre trial, including 256 healthy woman undergoing routine screening mammography with BI-RADS-1 results and 178 women with newly diagnosed breast cancer. This was a two-phase study: an initial training and calibration phase, followed by a two-armed blinded evaluation phase (52 healthy and 66 with breast cancer). 3DIRI data sets were acquired using a non-contact, no radiation system.Results: The sensitivity and specificity of functional infrared imaging in providing the correct risk for the presence of breast cancer were 90.9 % and 72.5 %, respectively. The area under the ROC curve was 86 %. Forty-two of the 60 (70 %) cancers in women correctly classified by the system as suspicious were smaller than 20 mm in size.Conclusion: The preliminary blinded results of this novel technology show sufficient performance of functional infrared imaging in providing risk assessment for breast cancer to warrant further clinical studies.Key Points: • 3D functional infrared imaging (3DIRI) provides new metabolic signatures from breast lesions. • 3DIRI offers high sensitivity for risk assessment of breast cancer. • It also has reasonable specificity. • This initial experience warrants further evaluation in larger clinical trials. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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