Optimisation of an automated drusen-quantifying software for the analysis of drusen distribution in patients with age-related macular degeneration.
Purpose: The purpose of this study is to optimise the settings of the Retinal Image Analysis Laboratory (RIALAB), a semi-automatic drusen quantification software, in planning for high-throughput quantification of drusen in clinical studies of age-related macular degeneration (AMD).Patients and Metho...
| Publicado en: | Eye (0950-222X) Vol. 27; no. 4; pp. 554 - 561 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104270003&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104270003 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0950222X LK5 jtl: Eye (0950-222X) issn: 0950222X maglogo: Y pubinfo: dt: Apr2013 vid: 27 iid: 4 pid: 2579 pub: Springer Nature place: Dordrecht, <Blank> artinfo: ui: 104270003 NLM23306729 2012081847 10.1038/eye.2012.292 NLM23306729 PMC3625998 104270003 ppf: 554 ppct: 7 formats: tig: atl: Optimisation of an automated drusen-quantifying software for the analysis of drusen distribution in patients with age-related macular degeneration. aug: au: Ong, B B Lee, N Lee, W P Pearce, E Sivaprasad, S Klaver, C C Smith, R T Chong, N V affil: Oxford Eye Hospital and the University of Oxford, Oxford, UK. sug: subj: Retinal Diseases Diagnosis Software Aged Algorithms Prospective Studies Female Human Macular Degeneration Diagnosis Male Middle Age Risk Factors Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Purpose: The purpose of this study is to optimise the settings of the Retinal Image Analysis Laboratory (RIALAB), a semi-automatic drusen quantification software, in planning for high-throughput quantification of drusen in clinical studies of age-related macular degeneration (AMD).Patients and Methods: A comparison of five different settings in RIALAB was made on 67 images from the Rotterdam eye study (population-based study) and 56 images from the fellow eye of patients with active neovascular AMD in King's College Hospital, London (hospital-based study).Results: The 'Few Outer' setting was the best setting, with it being most appropriate for 52 (77.6%) of the Rotterdam cohort and 47 (83.9%) for the London cohort. Pearson's χ(2)-test revealed both results to be statistically significant (P<0.0001).Conclusions: RIALAB is a viable algorithm and software package that can detect, quantify, and analyse drusen efficiently in both population-based and hospital-based studies. We have shown that the 'Few Outer' drusen setting can be employed as the default setting, with fine-tuning only needed in a minority of cases, thus helping to speed up workflow. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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