Inflammatory mediator patterns in tracheal aspirate and their association with bronchopulmonary dysplasia in very low birth weight neonates.
Objective:Alterations in inflammatory mediators are an important finding in neonates who develop bronchopulmonary dysplasia (BPD); however, there is a lack of research examining the relationship between multiple inflammatory mediators in premature neonates and the development of BPD. This study inve...
| Publicado en: | Journal of Perinatology Vol. 33; no. 5; pp. 383 - 388 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104282709&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104282709 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07438346 DZF jtl: Journal of Perinatology issn: 07438346 maglogo: Y pubinfo: dt: May2013 vid: 33 iid: 5 pid: 2579 pub: Springer Nature place: Dordrecht, <Blank> artinfo: ui: 104282709 87354293 10.1038/jp.2012.125 NLM23047424 104282709 ppf: 383 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Inflammatory mediator patterns in tracheal aspirate and their association with bronchopulmonary dysplasia in very low birth weight neonates. aug: au: Schneibel, K R Fitzpatrick, A M Ping, X-D Brown, L A S Gauthier, T W affil: Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA sug: subj: Bronchopulmonary Dysplasia Diagnosis Fluids and Secretions Analysis Human Funding Source Infant, Low Birth Weight Data Analysis Software Mann-Whitney U Test Fisher's Exact Test Predictive Value of Tests Sensitivity and Specificity ab: Objective:Alterations in inflammatory mediators are an important finding in neonates who develop bronchopulmonary dysplasia (BPD); however, there is a lack of research examining the relationship between multiple inflammatory mediators in premature neonates and the development of BPD. This study investigated whether the distribution of 12 inflammatory mediators detected in the tracheal aspirate (TA) of neonates within 24 h of birth could differentiate between neonates who did and who did not develop BPD.Study design:TA samples were collected from 27 very low birth weight neonates (BPD+=11), and the concentrations of 12 biomarkers associated with BPD were determined. Linear discriminant analysis (LDA) was used to classify neonates into two outcome groups.Result:LDA based on the 12 measured biomarkers displayed a significant level of discriminant function (P=0.007).Conclusion:Using linear discriminant analysis, predictive models of BPD can be generated. Our results suggest that multiple inflammatory mediators collected within 24 h of birth may be used to classify neonates into who will and who will not develop BPD. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|