Change in the contractile behavior of muscle fibers in subjects with primary muscle dysfunction.
The mechanical and metabolic characteristics of skeletal muscle fibers can interfere with muscle contractile performance in healthy subjects. Few studies have investigated the degree of association between muscle function and muscle fiber morphology in patients with myopathy. A biopsy was obtained f...
| Publicado en: | NeuroRehabilitation Vol. 32; no. 3; pp. 601 - 609 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104282993&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104282993 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10538135 3RE jtl: NeuroRehabilitation issn: 10538135 maglogo: N pubinfo: dt: 2013 vid: 32 iid: 3 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 104282993 87383562 10.3233/NRE-130882 NLM23648614 104282993 ppf: 601 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Change in the contractile behavior of muscle fibers in subjects with primary muscle dysfunction. aug: au: Back, Claudio Gregório Nuernberg Benedini-Elias, Priscila C.O. Mattiello, Stela M. Sobreira, Claudia Martinez, Edson Z. Mattiello-Sverzut, Ana Claudia affil: Faculty of Medicine of Ribeirão Preto, Medicine and Rehabilitation of the Locomotor Apparatus, Department of Biomechanics, University of São Paulo, Ribeirão Preto, São Paulo, Brazil sug: subj: Muscular Diseases Physiopathology Muscle Contraction Physiology Human Funding Source Torque Biopsy Spearman's Rank Correlation Coefficient Case Control Studies Male Female Adolescence Adult Descriptive Statistics Middle Age Data Analysis Software Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: The mechanical and metabolic characteristics of skeletal muscle fibers can interfere with muscle contractile performance in healthy subjects. Few studies have investigated the degree of association between muscle function and muscle fiber morphology in patients with myopathy. A biopsy was obtained from the left biceps brachii muscle of 12 subjects with myopathic disorders. The relative cross-sectional area of type 2 fibers and their subtypes was determined by the ATPase technique. Relative torque (RT) was calculated by dividing isokinetic elbow flexion peak torque (PT) values (90 and 180° s-1) by isometric PT values. Correlations were analyzed using Spearman's coefficient (r). The relative cross-sectional area of type 2b fibers was positively correlated with RT90 (r = 0.71, P = 0.009) and RT180 (r = 0.73, P = 0.007). The relative cross-sectional area of type 2a fibers showed a moderate and negative correlation with RT180 (r = -0.62, P = 0.03) and a low correlation with RT90 (r = -0.57, P = 0.05). In contrast to healthy subjects, patients with myopathy presented changes in the contractile behavior of type 2a fibers and compensatory adaptations in type 2b fibers. The results suggest that RT in combination with morphometric parameters provides data regarding muscle function in patients with myopathic disorders and can contribute to the establishment of therapeutic exercises. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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