Automated, Foot-Bone Registration Using Subdivision-Embedded Atlases for Spatial Mapping of Bone Mineral Density.

We present an atlas-based registration method for bones segmented from quantitative computed tomography (QCT) scans, with the goal of mapping their interior bone mineral densities (BMDs) volumetrically. We introduce a new type of deformable atlas, called subdivision-embedded atlas, which consists of...

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Detalles Bibliográficos
Publicado en:Journal of Digital Imaging Vol. 26; no. 3; pp. 554 - 563
Autores principales: Liu, Lu, Commean, Paul, Hildebolt, Charles, Sinacore, Dave, Prior, Fred, Carson, James, Kakadiaris, Ioannis, Ju, Tao
Formato: research tables/charts Journal Article
Publicado: Springer Nature Jun2013
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jun2013
      vid: 26
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      pub: Springer Nature
      place: New York, New York
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        atl: Automated, Foot-Bone Registration Using Subdivision-Embedded Atlases for Spatial Mapping of Bone Mineral Density.
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          Liu, Lu
          Commean, Paul
          Hildebolt, Charles
          Sinacore, Dave
          Prior, Fred
          Carson, James
          Kakadiaris, Ioannis
          Ju, Tao
        affil: Department of Computer Science and Engineering, Washington University, 1 Brookings Dr St. Louis 63130 USA
      sug:
        subj:
          Bone Density
          Tarsal Bones Radiography
          Tomography, X-Ray Computed Methods
          Radiographic Image Enhancement Methods
          Radiographic Image Interpretation, Computer-Assisted
          Metatarsal Bones Radiography
          Reference Tools
          Evaluation Research
          Repeated Measures
          Multivariate Analysis of Variance
          Adult
          Female
          Male
          Human
          Funding Source
          Adult: 19-44 years
          Female
          Male
      ab: We present an atlas-based registration method for bones segmented from quantitative computed tomography (QCT) scans, with the goal of mapping their interior bone mineral densities (BMDs) volumetrically. We introduce a new type of deformable atlas, called subdivision-embedded atlas, which consists of a control grid represented as a tetrahedral subdivision mesh and a template bone surface embedded within the grid. Compared to a typical lattice-based deformation grid, the subdivision control grid possesses a relatively small degree of freedom tailored to the shape of the bone, which allows efficient fitting onto subjects. Compared with previous subdivision atlases, the novelty of our atlas lies in the addition of the embedded template surface, which further increases the accuracy of the fitting. Using this new atlas representation, we developed an efficient and fully automated pipeline for registering atlases of 12 tarsal and metatarsal bones to a segmented QCT scan of a human foot. Our evaluation shows that the mapping of BMD enabled by the registration is consistent for bones in repeated scans, and the regional BMD automatically computed from the mapping is not significantly different from expert annotations. The results suggest that our improved subdivision-based registration method is a reliable, efficient way to replace manual labor for measuring regional BMD in foot bones in QCT scans.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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