Amikacin population pharmacokinetics in critically ill Kuwaiti patients.
Amikacin pharmacokinetic data in Kuwaiti (Arab) intensive care unit (ICU) patients are lacking. Fairly sparse serum amikacin peak and trough concentrations data were obtained from adult Kuwaiti ICU patients. The data were analysed using a nonparametric adaptive grid (NPAG) maximum likelihood algorit...
| Publicado en: | BioMed Research International Vol. 2013; pp. 202818 - 202819 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104286978&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104286978 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104286978 104286978 2012116571 NLM23484093 PMC3581152 104286978 ppf: 202818 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Amikacin population pharmacokinetics in critically ill Kuwaiti patients. aug: au: Matar, Kamal M Al-lanqawi, Yousef Abdul-Malek, Kefaya Jelliffe, Roger affil: Department of Pharmacology & Therapeutics, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Kuwait City 13110, Kuwait. kamal@hsc.edu.kw sug: subj: Algorithms Amikacin Pharmacokinetics Antibiotics Pharmacokinetics Arabs Models, Biological Adult Aged Aged, 80 and Over Amikacin Administration and Dosage Antibiotics Administration and Dosage Critical Illness Female Human Kuwait Male Middle Age Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Amikacin pharmacokinetic data in Kuwaiti (Arab) intensive care unit (ICU) patients are lacking. Fairly sparse serum amikacin peak and trough concentrations data were obtained from adult Kuwaiti ICU patients. The data were analysed using a nonparametric adaptive grid (NPAG) maximum likelihood algorithm. The estimations of the developed model were assessed using mean error (ME) as a measure of bias and mean squared error (MSE) as a measure of precision. A total of 331 serum amikacin concentrations were obtained from 56 patients. The mean (± SD) model parameter values found were Vc = 0.2302 ± 0.0866 L/kg, kslope = 0.004045 ± 0.00705 min per unit of creatinine clearance, k12 = 2.2121 ± 5.506 h(-1), and k21 = 1.431 ± 2.796 h(-1). The serum concentration data were estimated with little bias (ME = -0.88) and good precision (MSE = 13.08). The present study suggests that amikacin pharmacokinetics in adult Kuwaiti ICU patients are generally rather similar to those found in other patients. This population model would provide useful guidance in developing initial amikacin dosage regimens for such patients, especially using multiple model (MM) dosage design, followed by appropriate Bayesian adaptive control, to optimize amikacin dosage regimens for each individual patient. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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