Toxicity of silver nanoparticles at the air-liquid interface.
Silver nanoparticles are one of the most prevalent nanomaterials in consumer products. Some of these products are likely to be aerosolized, making silver nanoparticles a high priority for inhalation toxicity assessment. To study the inhalation toxicity of silver nanoparticles, we have exposed cultur...
| Publicado en: | BioMed Research International Vol. 2013; pp. 328934 - 328935 |
|---|---|
| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104286994&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104286994 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104286994 2012116587 NLM23484109 PMC3591145 104286994 ppf: 328934 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Toxicity of silver nanoparticles at the air-liquid interface. aug: au: Holder, Amara L Marr, Linsey C affil: Department of Civil and Environmental Engineering, Virginia Tech, 411 Durham Hall (0246), Blacksburg, VA 24061, USA. sug: subj: Cytotoxins Adverse Effects Nanotechnology Adverse Effects Nickel Adverse Effects Oxides Adverse Effects Silver Compounds Adverse Effects Aerosols Cells Cytotoxins Pharmacodynamics Nickel Pharmacodynamics Oxides Pharmacodynamics Silver Adverse Effects Silver Pharmacodynamics Silver Compounds Pharmacodynamics ab: Silver nanoparticles are one of the most prevalent nanomaterials in consumer products. Some of these products are likely to be aerosolized, making silver nanoparticles a high priority for inhalation toxicity assessment. To study the inhalation toxicity of silver nanoparticles, we have exposed cultured lung cells to them at the air-liquid interface. Cells were exposed to suspensions of silver or nickel oxide (positive control) nanoparticles at concentrations of 2.6, 6.6, and 13.2 ¿ g cm(-2) (volume concentrations of 10, 25, and 50 ¿ g ml(-1)) and to 0.7 ¿ g cm(-2) silver or 2.1 ¿ g cm(-2) nickel oxide aerosol at the air-liquid interface. Unlike a number of in vitro studies employing suspensions of silver nanoparticles, which have shown strong toxic effects, both suspensions and aerosolized nanoparticles caused negligible cytotoxicity and only a mild inflammatory response, in agreement with animal exposures. Additionally, we have developed a novel method using a differential mobility analyzer to select aerosolized nanoparticles of a single diameter to assess the size-dependent toxicity of silver nanoparticles. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|