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Growth induction and low-oxygen apoptosis inhibition of human CD34+ progenitors in collagen gels.

Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipi...

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Published in:BioMed Research International Vol. 2013; pp. 542810 - 542811
Main Authors: Avitabile, Daniele, Salchert, Katrin, Werner, Carsten, Capogrossi, Maurizio C, Pesce, Maurizio
Format: Journal Article
Published: Wiley-Blackwell 2013
Online Access:View this record in EBSCOhost
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      dt: 2013
      vid: 2013
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        atl: Growth induction and low-oxygen apoptosis inhibition of human CD34+ progenitors in collagen gels.
      aug:
        au:
          Avitabile, Daniele
          Salchert, Katrin
          Werner, Carsten
          Capogrossi, Maurizio C
          Pesce, Maurizio
        affil: Laboratorio di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino, 20138 Milano, Italy.
      sug:
        subj:
          Antigens, Surface Metabolism
          Apoptosis
          Collagen
          Oxygen Metabolism
          Stem Cells
          Cell Physiology
          Fetal Blood
          Flow Cytometry
          Gels
      ab: Various reports have indicated low survival of injected progenitors into unfavorable environments such as the ischemic myocardium or lower limb tissues. This represents a major bottleneck in stem-cell-based cardiovascular regenerative medicine. Strategies to enhance survival of these cells in recipient tissues have been therefore sought to improve stem cell survival and ensure long-term engraftment. In the present contribution, we show that embedding human cord blood-derived CD34(+) cells into a collagen I-based hydrogel containing cytokines is a suitable strategy to promote stem cell proliferation and protect these cells from anoxia-induced apoptosis.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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