Supplementation with Selenium-Enriched Yeast Attenuates Brain Metastatic Growth.
Metastases are the leading cause of cancer mortality and their development may be affected by diet. The aim of this study was to compare the effects of dietary supplementation with different selenium (Se) compounds on the dynamics of brain metastasis development in a novel mouse model. Mice were fed...
| Publicado en: | Nutrition & Cancer Vol. 65; no. 4; pp. 563 - 571 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Taylor & Francis Ltd
May2013
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104289055&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104289055 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: May2013 vid: 65 iid: 4 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104289055 87620963 10.1080/01635581.2013.775315 NLM23659448 104289055 ppf: 563 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Supplementation with Selenium-Enriched Yeast Attenuates Brain Metastatic Growth. aug: au: Wrobel, Jagoda K. Seelbach, Melissa J. Chen, Lei Power, Ronan F. Toborek, Michal affil: Department of Biochemistry and Molecular Biology , University of Miami School of Medicine , Miami , Florida , USA sug: subj: Brain Neoplasms Therapy Dietary Supplementation Selenium Administration and Dosage Outcomes (Health Care) Yeasts Nutrition Animal Studies Brain Neoplasms Physiopathology Neoplasm Metastasis Mortality Neoplasm Metastasis Diagnosis Neoplasm Metastasis Complications Mice Diagnostic Imaging Body Weight Data Analysis Descriptive Statistics ab: Metastases are the leading cause of cancer mortality and their development may be affected by diet. The aim of this study was to compare the effects of dietary supplementation with different selenium (Se) compounds on the dynamics of brain metastasis development in a novel mouse model. Mice were fed experimental diets enriched (1 mg/kg) with sodium selenite (Se-S), seleno-1-methionine (Se-Meth), a yeast-derived organic form of selenium (Se-Yeast), or a control diet (Se < 0.05 mg/kg) for 20 wk. At the end of the feeding period, animals were injected with luciferase-tagged K1735 (K1735-Luc) melanoma cells into the brain vasculature. The development of brain metastatic tumors was monitored for 2 wk following injection. Mice bearing brain metastatic tumors and fed Se-Yeast- or Se-S-enriched diets displayed a higher survival rate compared with other experimental and control groups. Importantly, Se-Yeast supplementation decreased the growth of brain metastatic tumors as determined by the measurement of the intensity of the bioluminescent signal emitted by K1735-Luc cells upon reaction with luciferin. Different chemical forms of Se have distinct effects on the development of brain metastases. Organic Se in the form of Se-Yeast may be a valuable agent in suppression of brain metastatic disease. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|