Benchmarking therapeutic drug monitoring software: a review of available computer tools.
Therapeutic drug monitoring (TDM) aims to optimize treatments by individualizing dosage regimens based on the measurement of blood concentrations. Dosage individualization to maintain concentrations within a target range requires pharmacokinetic and clinical capabilities. Bayesian calculations curre...
| Publicado en: | Clinical Pharmacokinetics Vol. 52; no. 1; pp. 9 - 23 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104294751&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104294751 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03125963 C4U jtl: Clinical Pharmacokinetics issn: 03125963 maglogo: N pubinfo: dt: 2013 vid: 52 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104294751 NLM23196713 2011900099 10.1007/s40262-012-0020-y NLM23196713 104294751 ppf: 9 ppct: 14 formats: tig: atl: Benchmarking therapeutic drug monitoring software: a review of available computer tools. aug: au: Fuchs A Csajka C Thoma Y Buclin T Widmer N Fuchs, Aline Csajka, Chantal Thoma, Yann Buclin, Thierry Widmer, Nicolas affil: Division of Clinical Pharmacology, Service of Biomedicine, Department of Laboratory, Hôpital de Beaumont, Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1011, Lausanne, Switzerland sug: subj: Drug Monitoring Equipment and Supplies Software Probability Costs and Cost Analysis Dose-Response Relationship, Drug Human Information Retrieval Models, Biological User-Computer Interface ab: Therapeutic drug monitoring (TDM) aims to optimize treatments by individualizing dosage regimens based on the measurement of blood concentrations. Dosage individualization to maintain concentrations within a target range requires pharmacokinetic and clinical capabilities. Bayesian calculations currently represent the gold standard TDM approach but require computation assistance. In recent decades computer programs have been developed to assist clinicians in this assignment. The aim of this survey was to assess and compare computer tools designed to support TDM clinical activities. The literature and the Internet were searched to identify software. All programs were tested on personal computers. Each program was scored against a standardized grid covering pharmacokinetic relevance, user friendliness, computing aspects, interfacing and storage. A weighting factor was applied to each criterion of the grid to account for its relative importance. To assess the robustness of the software, six representative clinical vignettes were processed through each of them. Altogether, 12 software tools were identified, tested and ranked, representing a comprehensive review of the available software. Numbers of drugs handled by the software vary widely (from two to 180), and eight programs offer users the possibility of adding new drug models based on population pharmacokinetic analyses. Bayesian computation to predict dosage adaptation from blood concentration (a posteriori adjustment) is performed by ten tools, while nine are also able to propose a priori dosage regimens, based only on individual patient covariates such as age, sex and bodyweight. Among those applying Bayesian calculation, MM-USC*PACK© uses the non-parametric approach. The top two programs emerging from this benchmark were MwPharm© and TCIWorks. Most other programs evaluated had good potential while being less sophisticated or less user friendly. Programs vary in complexity and might not fit all healthcare settings. Each software tool must therefore be regarded with respect to the individual needs of hospitals or clinicians. Programs should be easy and fast for routine activities, including for non-experienced users. Computer-assisted TDM is gaining growing interest and should further improve, especially in terms of information system interfacing, user friendliness, data storage capability and report generation. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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