Utility of the inversion scout sequence (TI scout) in diagnosing myocardial amyloid infiltration.
To evaluate the utility of inversion scout (TI-scout) obtained during cardiac magnetic resonance imaging (CMR) in diagnosing myocardial amyloid infiltration. A retrospective analysis of CMR exams in 39 patients (24 males, age range 29-77 years) was performed. Imaging was performed on a 1.5T system,...
| Publicado en: | International Journal of Cardiovascular Imaging Vol. 29; no. 1; pp. 103 - 113 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104295485&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104295485 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15695794 1HHY jtl: International Journal of Cardiovascular Imaging issn: 15695794 maglogo: N pubinfo: dt: Jan2013 vid: 29 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104295485 NLM22527255 2011901397 10.1007/s10554-012-0042-4 NLM22527255 PMC3586540 104295485 ppf: 103 ppct: 10 formats: tig: atl: Utility of the inversion scout sequence (TI scout) in diagnosing myocardial amyloid infiltration. aug: au: Pandey T Jambhekar K Shaikh R Lensing S Viswamitra S Pandey, Tarun Jambhekar, Kedar Shaikh, Raja Lensing, Shelly Viswamitra, Sanjaya affil: University of Arkansas for Medical Sciences, Slot 556, 4301 West Markham, Little Rock, AR 72205, USA sug: subj: Amyloidosis Diagnosis Myocardial Diseases Diagnosis Magnetic Resonance Imaging Myocardium Pathology Adult Aged Amyloidosis Pathology Amyloidosis Physiopathology Myocardial Diseases Pathology Myocardial Diseases Physiopathology Chi Square Test Female Human Image Interpretation, Computer Assisted Male Middle Age Predictive Value of Tests Retrospective Design Sensitivity and Specificity Time Factors Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: To evaluate the utility of inversion scout (TI-scout) obtained during cardiac magnetic resonance imaging (CMR) in diagnosing myocardial amyloid infiltration. A retrospective analysis of CMR exams in 39 patients (24 males, age range 29-77 years) was performed. Imaging was performed on a 1.5T system, and included steady state cine, post contrast TI-scout and delayed enhancement images. Evaluations included studies in 13 patients with myocardial amyloidosis and 26 patients without myocardial amyloidosis. To characterize abnormal nulling, the time to myocardial nulling on the TI scout was compared to the null times of the blood pool and spleen for each scan. The sensitivity and specificity of different tissue nulling abnormalities for myocardial amyloidosis were computed. The null times of tissues in 18/26 (69%) patients in the non-amyloid group followed a consistent order with the blood pool null time preceding the myocardial nulling which was equal to that of splenic nulling (Type 1 pattern). This order differed in all 13 patients with myocardial amyloidosis described as three non-mutually exclusive nulling categories: 10 patients had myocardial null time preceding or coincident with blood pool (Type 2 pattern); in 11 patients myocardial null time was non-coincident with splenic nulling (Type 3 pattern); and in 8 patients myocardial null time was non-coincident with both blood pool AND splenic nulling (Type 4 pattern). While no patient exhibited Type 4 nulling pattern in the non-amyloid group, 1/26 patient had a Type 2 and 7/26 patients had a Type 3 nulling pattern. A sensitivity of 100% was obtained when either Type 2 OR Type 3 nulling was present while a specificity of 100% was obtained when both Type 2 AND Type 3 nulling were present together (Type 4 pattern). Our study demonstrates that the pattern of nulling on the TI scout sequence CMR has potential diagnostic utility for the presence of myocardial amyloidosis. The temporal pattern of myocardial, blood pool and splenic nulling needs to be carefully evaluated on the TI scout sequence and could prove useful in other infiltrative cardiomyopathies. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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