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Infliximab Treatment in Resistant Pyoderma Gangrenosum: A Case Report.

Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis consisting of nodules and pustules that ulcerate. Pyoderma gangrenosum is associated with autoimmune disorders such as inflammatory bowel disease, spondyloarthritis, and rheumatoid arthritis. In mild disease, therapy consists of local...

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Published in:Turkish Journal of Physical Medicine & Rehabilitation / Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi Vol. 58; no. 4; pp. 332 - 335
Main Authors: Durmaz, Yunus, BİLgİCİ, Ayhan, CİL, Erhan Erdem, Kuru, Ãmer
Format: case study pictorial tables/charts Journal Article
Published: Turkish Society of Physical Medicine & Rehabilitation Dec2012
Online Access:View this record in EBSCOhost
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      jtl: Turkish Journal of Physical Medicine & Rehabilitation / Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi
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      dt: Dec2012
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      pub: Turkish Society of Physical Medicine & Rehabilitation
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        atl: Infliximab Treatment in Resistant Pyoderma Gangrenosum: A Case Report.
      aug:
        au:
          Durmaz, Yunus
          BİLgİCİ, Ayhan
          CİL, Erhan Erdem
          Kuru, Ãmer
        affil: Ondokuz Mayıs University, Department of Physical Medicine and Rehabilitation, Samsun, Turkey
      sug:
        subj:
          Pyoderma Gangrenosum Drug Therapy
          Infliximab Therapeutic Use
          Drug Resistance
          Comorbidity
          Treatment Outcomes
          Pyoderma Gangrenosum Diagnosis
          Adult
          Male
          Adult: 19-44 years
          Male
      ab: Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis consisting of nodules and pustules that ulcerate. Pyoderma gangrenosum is associated with autoimmune disorders such as inflammatory bowel disease, spondyloarthritis, and rheumatoid arthritis. In mild disease, therapy consists of local wound care and topical or intralesional corticosteroids. For more severe disease, systemic agents are necessary. Herein, we present the case of a patient with steroid resistant pyederma gangrenosum associated with ulcerative colitis and ankylosing spondylitis who responded well to infliximab, a tumor necrosis factor blocker. Biological agents (anti-TNF) may be alternative treatment options in patients with resistant PG.
      pubtype: Academic Journal
      doctype:
        case study
        pictorial
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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