Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction: Sequential MR Imaging Using a 3T Clinical Scanner.
Purpose. To evaluate whether 3T clinical MRI with a small-animal coil and gradient-echo (GE) sequence could be used to characterize long-termleft ventricular remodelling (LVR) following nonreperfusedmyocardial infarction (MI) using semi-automatic segmentation software (SASS) in a rat model. Material...
| Publicado en: | Journal of Biomedicine & Biotechnology Vol. 2012; pp. 1 - 11 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104297839&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104297839 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2012 vid: 2012 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104297839 104297839 2011906761 NLM23118511 PMC3479400 104297839 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction: Sequential MR Imaging Using a 3T Clinical Scanner. aug: au: Saleh, Muhammad G. Sharp, Sarah-Kate Alhamud, Alkathafi Spottiswoode, Bruce S. van der Kouwe, Andre J. W. Davies, Neil H. Franz, Thomas Meintjes, Ernesta M. affil: MRC/UCT Medical Imaging Research Unit, Department of Human Biology, University of Cape Town, Observatory 7925, South Africa sug: subj: Ventricular Remodeling Magnetic Resonance Imaging Methods Myocardial Infarction Pathology Heart Ventricle, Left Pathology Animal Studies Rats Ventricular Function, Left Descriptive Statistics Unpaired T-Tests Funding Source ab: Purpose. To evaluate whether 3T clinical MRI with a small-animal coil and gradient-echo (GE) sequence could be used to characterize long-termleft ventricular remodelling (LVR) following nonreperfusedmyocardial infarction (MI) using semi-automatic segmentation software (SASS) in a rat model. Materials and Methods. 5 healthy rats were used to validate left ventricular mass (LVM) measured by MRI with postmortem values. 5 sham and 7 infarcted rats were scanned at 2 and 4 weeks after surgery to allow for functional and structural analysis of the heart. Measurements included ejection fraction (EF), end-diastolic volume (EDV), endsystolic volume (ESV), and LVM. Changes in different regions of the heart were quantified using wall thickness analyses. Results. LVM validation in healthy rats demonstrated high correlation between MR and postmortem values. Functional assessment at 4 weeks after MI revealed considerable reduction in EF, increases in ESV, EDV, and LVM, and contractile dysfunction in infarcted and noninfarcted regions. Conclusion. Clinical 3T MRI with a small animal coil and GE sequence generated images in a rat heart with adequate signal-to-noise ratio (SNR) for successful semiautomatic segmentation to accurately and rapidly evaluate long-term LVR after MI. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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