Acanthus ebracteatus Vahl. Ethanol Extract Enhancement of the Efficacy of the Collagen Scaffold in Wound Closure: A Study in a Full-Thickness-Wound Mouse Model.
Acanthus ebracteatus Vahl. is a Thai herb that is effective in wound healing. We sought to quantitatively determine whether or not the combined application of Acanthus ebracteatus Vahl. and a collagen scaffold will increase wound closure and angiogenesis. Balb/cmice (body weight: 22-25 g) were anest...
| Publicado en: | Journal of Biomedicine & Biotechnology Vol. 2012; pp. 1 - 9 |
|---|---|
| Autores principales: | , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2012
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104297883&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104297883 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2012 vid: 2012 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104297883 104297883 2011906804 NLM23093862 PMC3471030 104297883 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Acanthus ebracteatus Vahl. Ethanol Extract Enhancement of the Efficacy of the Collagen Scaffold in Wound Closure: A Study in a Full-Thickness-Wound Mouse Model. aug: au: Jutamas Somchaichana Tanom Bunaprasert Suthiluk Patumraj affil: Inter-Department of Physiology, Graduate School and Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand sug: subj: Wound Healing Drug Effects Wounds, Penetrating Therapy Plant Extracts Therapeutic Use Bandages and Dressings Animal Studies Mice Neovascularization, Physiologic Combined Modality Therapy Skin Injuries Skin Drug Effects Descriptive Statistics One-Way Analysis of Variance Post Hoc Analysis Funding Source ab: Acanthus ebracteatus Vahl. is a Thai herb that is effective in wound healing. We sought to quantitatively determine whether or not the combined application of Acanthus ebracteatus Vahl. and a collagen scaffold will increase wound closure and angiogenesis. Balb/cmice (body weight: 22-25 g) were anesthetized with sodium thiopental. The dorsal skin incisionmeasuring 1.5 × 1.5 cmwas made and then deepened using scissors to produce a full-thickness incision down to the level of the panniculus carnosus. The size of the wound was approximately 10% of the total body surface area. The collagen sheet was implanted onto the wound. Animals were divided into 4 major groups as follows: wound with normal saline (W-NSS), wound treated with 0.3 g/kg BW of Acanthus ebracteatus Vahl. extract (W-AE (0.3 g/kg.bw)), wound implanted with collagen scaffold (W-Coll), and wound implanted with collagen scaffold and treated with 0.3 g/kg BWof Acanthus ebracteatus Vahl. (W-Coll-AE combination). On day 14, theW-Coll-AE group showed decreased wound areas and increased capillary vascularity (CV) when compared to the other 3 groups, W-NSS, W-AE0.3, and W-Coll. In the present study, the combination of AE0.3 with collagen showed the best effect on skin angiogenesis and promoted wound closure with less neutrophil infiltration. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|