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Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy: A Microscopic Study Contrasted with the Hormonal Assays.

We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology using stereological assays in male rats. After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional light microscopy. Microscopic analys...

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Publicado en:Journal of Biomedicine & Biotechnology Vol. 2012; pp. 1 - 7
Autores principales: Venâncio, Daniel P., Andersen, Monica L., Vilamaior, Patricia S. L., Santos, Fernanda C., Zager, Adriano, Tufik, Sérgio, Taboga, Sebastião R., De Mello, Marco T.
Formato: pictorial research tables/charts Journal Article
Publicado: Wiley-Blackwell 2012
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 2012
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        atl: Sleep Deprivation Alters Rat Ventral Prostate Morphology, Leading to Glandular Atrophy: A Microscopic Study Contrasted with the Hormonal Assays.
      aug:
        au:
          Venâncio, Daniel P.
          Andersen, Monica L.
          Vilamaior, Patricia S. L.
          Santos, Fernanda C.
          Zager, Adriano
          Tufik, Sérgio
          Taboga, Sebastião R.
          De Mello, Marco T.
        affil: Departamento de Nutrição, Universidade Federal de S;ão Paulo (UNIFESP-EPM), Rua Marselhesa, 630, Vila Clementino, 04020-620 São Paulo, SP, Brazil
      sug:
        subj:
          Sleep Deprivation Pathology
          Prostate Metabolism
          Prostate Physiopathology
          Atrophy
          Sleep, REM
          Animal Studies
          Rats
          Funding Source
          Testosterone Blood
          Sleep Deprivation Blood
          Staining and Labeling Methods
          Descriptive Statistics
          One-Way Analysis of Variance
          Post Hoc Analysis
          Data Analysis Software
      ab: We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology using stereological assays in male rats. After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional light microscopy. Microscopic analysis of the prostate reveals that morphology of this gland was altered after 96 h of PSD and 21 days of SR, with the most important alterations occurring in the epithelium and stroma in the course of both procedures compared with the control group. Both 96 h PSD and 21-day SR rats showed lower serum testosterone and higher corticosterone levels than control rats. The significance of our result referring to the sleep deprivation was responsible for deep morphological alterations in ventral prostate tissue, like to castration microscopic modifications. This result is due to the marked alterations in hormonal status caused by PSD and SR.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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