Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury.
Phosphocreatine (PCr) is a natural compound, which can donate high-energy phosphate group to ADP to synthesize ATP, even in the absence of oxygen and glucose. At present, it is widely used in cardiac and renal ischemia-reperfusion (IR) disease. In this study, to examine the protective efficacy of PC...
| Publicado en: | Journal of Biomedicine & Biotechnology Vol. 2012; pp. 1 - 8 |
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| Autores principales: | , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104298131&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104298131 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2012 vid: 2012 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104298131 104298131 2011907054 NLM22505804 PMC3312326 104298131 ppf: 1 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury. aug: au: Tiegang Li Nana Wang Min Zhao affil: Emergency Department, Shengjing Hospital of China Medical University, Shenyang 110004, China sug: subj: Neuroprotective Agents Pharmacodynamics Phosphocreatine Pharmacodynamics Infarction Drug Therapy Reperfusion Injury Drug Therapy Treatment Outcomes Rats Animal Studies Descriptive Statistics Data Analysis Software Repeated Measures Analysis of Variance Kruskal-Wallis Test Apoptosis Drug Effects Intracranial Pressure Drug Effects Funding Source ab: Phosphocreatine (PCr) is a natural compound, which can donate high-energy phosphate group to ADP to synthesize ATP, even in the absence of oxygen and glucose. At present, it is widely used in cardiac and renal ischemia-reperfusion (IR) disease. In this study, to examine the protective efficacy of PCr against cerebral IR, disodium creatine phosphate was injected intravenously into rats before focal cerebral IR. Intracranial pressure (ICP), neurological score, cerebral infarction volume, and apoptotic neurons were observed. Expression of caspase-3 and aquaporin-4 (AQP4) was analyzed. Compared with IR group, rats pretreated with PCr had better neurologic score, less infarction volume, fewer ultrastructural histopathologic changes, reduced apoptosis, and lower aquaporin-4 level. In conclusion, PCr is neuroprotective after transient focal cerebral IR injury. Such a protection might be associated with apoptosis regulating proteins. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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