Influences of Desmin and Keratin 19 on Passive Biomechanical Properties of Mouse Skeletal Muscle.
In skeletal muscle fibers, forces must be transmitted between the plasma membrane and the intracellular contractile lattice, and within this lattice between adjacent myofibrils. Based on their prevalence, biomechanical properties and localization, desmin and keratin intermediate filaments (IFs) are...
| Publicado en: | Journal of Biomedicine & Biotechnology Vol. 2012; pp. 1 - 13 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104298231&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104298231 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2012 vid: 2012 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104298231 104298231 2011907153 NLM22287836 PMC3263816 104298231 ppf: 1 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Influences of Desmin and Keratin 19 on Passive Biomechanical Properties of Mouse Skeletal Muscle. aug: au: Shah, Sameer B. Love, James M. O'Neill, Andrea Lovering, Richard M. Bloch, Robert J. affil: Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA; Departments of Orthopaedic Surgery and Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA sug: subj: Muscle, Skeletal Physiology Cytoskeletal Proteins Physiology Cell Membrane Physiology Muscle Fibers Physiology Animal Studies Mice Regression Analysis of Variance Post Hoc Analysis Two-Tailed Test Descriptive Statistics Data Analysis Software Muscular Diseases Familial and Genetic Muscular Diseases Pathology Weight-Bearing Cytoplasm Physiology Funding Source ab: In skeletal muscle fibers, forces must be transmitted between the plasma membrane and the intracellular contractile lattice, and within this lattice between adjacent myofibrils. Based on their prevalence, biomechanical properties and localization, desmin and keratin intermediate filaments (IFs) are likely to participate in structural connectivity and force transmission. We examined the passive load-bearing response of single fibers from the extensor digitorum longus (EDL) muscles of young (3 months) and aged (10months) wild-type, desmin-null, K19-null, and desmin/K19 double-null mice. Though fibers are more compliant in allmutant genotypes compared to wild-type, the structural response of each genotype is distinct, suggesting multiple mechanisms by which desmin and keratin influence the biomechanical properties of myofibers. This work provides additional insight into the influences of IFs on structure-function relationships in skeletal muscle. It may also have implications for understanding the progression of desminopathies and other IF-related myopathies. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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