Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia.
Waldenström macroglobulinemia (WM) is characterized by monoclonal gammopathy, usually IgM, in association with lymphoplasmacytic lymphoma (LPL). Little is known of the expression of nuclear proteins involved in B-cell development in LPL/WM. In this study, the expression patterns of PAX5/BSAP, MUM1/I...
| Publicado en: | American Journal of Clinical Pathology Vol. 139; no. 2; pp. 210 - 220 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Oxford University Press / USA
Feb2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104301570&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104301570 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00029173 2RW jtl: American Journal of Clinical Pathology issn: 00029173 maglogo: N pubinfo: dt: Feb2013 vid: 139 iid: 2 pid: 10398 pub: Oxford University Press / USA artinfo: ui: 104301570 104301570 NLM23355206 2011911498 10.1309/AJCP0YGM8BLFYHJY NLM23355206 104301570 ppf: 210 ppct: 10 formats: tig: atl: Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia. aug: au: Roberts MJ Chadburn A Ma S Hyjek E Peterson LC Roberts, Mark J Chadburn, Amy Ma, Shuo Hyjek, Elizabeth Peterson, LoAnn C affil: Department of Pathology, Northwestern University-Feinberg School of Medicine, Chicago, IL 60611, USA sug: subj: Proteins Metabolism Lymphoproliferative Disorders Metabolism Adult Aged Aged, 80 and Over Bone Marrow Immunology Bone Marrow Metabolism Bone Marrow Pathology Female Human Immunohistochemistry Methods Lymphocytes Metabolism Lymphocytes Pathology Male Middle Age B Lymphocytes Metabolism B Lymphocytes Pathology Glycoproteins Metabolism Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Waldenström macroglobulinemia (WM) is characterized by monoclonal gammopathy, usually IgM, in association with lymphoplasmacytic lymphoma (LPL). Little is known of the expression of nuclear proteins involved in B-cell development in LPL/WM. In this study, the expression patterns of PAX5/BSAP, MUM1/IRF4, and PRDM1/BLIMP1 were analyzed in plasma cells and lymphocytes in 29 cases of newly diagnosed LPL/WM by double immunohistochemical staining with CD138 and CD22. These patterns were compared with the expression profiles seen in normal bone marrow samples, reactive tonsils, and cases of plasma cell myeloma and marginal zone lymphoma. The median percentage of plasma cells coexpressing CD138 and PAX5 was significantly higher in LPL/WM compared with benign tissues (P = .001), marginal zone lymphoma (P = .002), and plasma cell myeloma (P < .0001), whereas the median percentage of plasma cells coexpressing CD138 and MUM1 was lower in LPL/WM than plasma cells in benign tissues (P = .02), marginal zone lymphoma (P = .001), and plasma cell myeloma (P = .0002). These findings show that a subset of plasma cells in LPL/WM demonstrates a nuclear protein expression pattern characteristic of the B-cell developmental program. Thus, the results better define the immunophenotypic profile of the neoplastic cells in LPL/WM. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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