Household endotoxin levels and the risk of non-Hodgkin lymphoma.
Objective: Endotoxin, a component of the outer membrane of gram-negative bacteria, elicits a strong innate and inflammatory immune response associated with the secretion of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α). Because TNF-α polymorphisms that increase TNF-α produ...
| Publicado en: | Cancer Causes & Control Vol. 24; no. 2; pp. 357 - 365 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104301672&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104301672 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Feb2013 vid: 24 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104301672 NLM23277417 2011911617 10.1007/s10552-012-0121-9 NLM23277417 PMC3800025 104301672 ppf: 357 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Household endotoxin levels and the risk of non-Hodgkin lymphoma. aug: au: Wang J Cozen W Thorne PS Berhane K Cerhan JR Hartge P Ward MH De Roos AJ Severson RK Morton LM Bernstein L Linet MS Colt JS Wang, Jun Cozen, Wendy Thorne, Peter S Berhane, Kiros Cerhan, James R Hartge, Patricia Ward, Mary H affil: Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, CA, USA sug: subj: Endotoxins Poisoning Environmental Exposure Adverse Effects Lymphoma, Non-Hodgkin's Epidemiology Aged Case Control Studies Family Characteristics Female Disease Susceptibility Human Lymphoma, Non-Hodgkin's Chemically Induced Lymphoma, Non-Hodgkin's Male Middle Age Risk Factors Registries, Disease United States Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objective: Endotoxin, a component of the outer membrane of gram-negative bacteria, elicits a strong innate and inflammatory immune response associated with the secretion of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α). Because TNF-α polymorphisms that increase TNF-α production are associated with an increased risk of non-Hodgkin lymphoma (NHL), we hypothesized that increased levels of household endotoxin would be associated with an increased NHL risk.Methods: We evaluated this association in the National Cancer Institute/Surveillance, Epidemiology and End Results (NCI/SEER) NHL multicenter population-based case-control study. Used vacuum cleaner bags were collected from participants during a home interview. Dust samples from the bags of 594 cases and 442 controls were analyzed for endotoxin [endotoxin unit (EU)/mg of dust] using the kinetic chromogenic Limulus amebocyte lysate assay. Multivariable logistic regression was used to estimate the effect of endotoxin on NHL risk adjusted for age, sex, race, education, study center, and farm exposure.Results: Endotoxin was not associated with NHL overall [odds ratio (OR) for highest quartile of endotoxin levels = 0.81, 95 % confidence interval (CI) = 0.55, 1.20; p for trend = 0.35] or with diffuse large B-cell lymphoma (OR = 0.63, 95 % CI = 0.34, 1.16; p = 0.31) or follicular lymphoma (OR = 1.07, 95 % CI = 0.61, 1.89; p = 0.73) subtypes. Both working and living on a farm were associated with higher household endotoxin levels compared to never working (p = 0.009) or living (p = 0.01) on a farm. Excluding farmers from the analysis did not change the results.Conclusions: We found no evidence of a role for household endotoxin in NHL etiology. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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