Effect of antenatal growth on brain white matter maturation in preterm infants at term using tract-based spatial statistics.
Background: White matter maturation of infants can be studied using diffusion tensor imaging (DTI). DTI of the white matter of the infant brain provides the best available clinical measures of brain tissue organisation and integrity.Objective: The purpose of this study was to compare white matter ma...
| Publicado en: | Pediatric Radiology Vol. 43; no. 1; pp. 80 - 86 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104312009&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104312009 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Jan2013 vid: 43 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104312009 NLM23160647 2011931416 10.1007/s00247-012-2509-9 NLM23160647 104312009 ppf: 80 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Effect of antenatal growth on brain white matter maturation in preterm infants at term using tract-based spatial statistics. aug: au: Lepomäki V Matomäki J Lapinleimu H Lehtonen L Haataja L Komu M Parkkola R Lepomäki, Virva Matomäki, Jaakko Lapinleimu, Helena Lehtonen, Liisa Haataja, Leena Komu, Markku Parkkola, Riitta affil: Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland sug: subj: Brain Pathology Magnetic Resonance Imaging Methods Infant, Premature Female Human Infant, Newborn Infant, Small for Gestational Age Male Nerve Fibers Pathology Infant, Newborn: birth-1 month Female Male ab: Background: White matter maturation of infants can be studied using diffusion tensor imaging (DTI). DTI of the white matter of the infant brain provides the best available clinical measures of brain tissue organisation and integrity.Objective: The purpose of this study was to compare white matter maturation between preterm infants born small for gestational age (SGA) and preterms with weight appropriate for gestational age (AGA) at birth.Materials and Methods: A total of 36 preterm infants were enrolled in the study (SGA, n = 9). A rater-independent method called tract-based spatial statistics (TBSS) was used to assess white matter maturation.Results: When measured by TBSS, the AGA infants showed higher fractional anisotrophy values in several white matter tracts than the SGA infants. Areas with significant differences included anterior thalamic radiation, corticospinal tract, forceps major and minor, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, superior longitudinal fasciculus, uncinate fasciculus, and superior longitudinal fasciculus (temporal part). No significant difference was found for mean diffusivity.Conclusion: As an objective and user-independent method, TBSS confirmed that preterm infants with impaired antenatal growth have impaired white matter maturation compared to preterm infants with normal antenatal growth. The differences were mainly detected in radiations that are myelinated first. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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