LDL-cholesterol-lowering effect of a dietary supplement with plant extracts in subjects with moderate hypercholesterolemia.
Purpose: Red yeast rice (RYR), sugar cane-derived policosanols (SCdP) and artichoke leaf extracts (ALEs) are currently incorporated alone or in combination into dietary supplements for their potential low-density-lipoprotein cholesterol (LDL-cholesterol)-lowering effects. Yet, there is no informatio...
| Publicado en: | European Journal of Nutrition Vol. 52; no. 2; pp. 547 - 558 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Mar2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104314594&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104314594 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2013 vid: 52 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104314594 85480606 10.1007/s00394-012-0357-x NLM22527287 104314594 ppf: 547 ppct: 11 formats: fmt: @attributes: type: P tig: atl: LDL-cholesterol-lowering effect of a dietary supplement with plant extracts in subjects with moderate hypercholesterolemia. aug: au: Ogier, Nicolas Amiot, Marie-Josèphe Georgé, Stéphane Maillot, Matthieu Mallmann, Cécilia Maraninchi, Marie Morange, Sophie Lescuyer, Jean-François Peltier, Sébastien Cardinault, Nicolas affil: Laboratoire Lescuyer, Department of Research, ZAC Belle-Aire Nord, 15 rue le Corbusier 17440 Aytré France sug: subj: Hypercholesterolemia Diet Therapy Dietary Supplements Plant Extracts Administration and Dosage Lipoproteins, LDL Cholesterol Drug Effects Human Randomized Controlled Trials Double-Blind Studies Adult Middle Age Lipids Blood Vitamins Blood Confidence Intervals Descriptive Statistics France Male Female Data Analysis Software T-Tests Diet Records Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Purpose: Red yeast rice (RYR), sugar cane-derived policosanols (SCdP) and artichoke leaf extracts (ALEs) are currently incorporated alone or in combination into dietary supplements for their potential low-density-lipoprotein cholesterol (LDL-cholesterol)-lowering effects. Yet, there is no information supporting the efficacy of this association on the reduction in LDL-cholesterol. The main objective of this study was to investigate the effects of a new dietary supplement (DS) with RYR, SCdP and ALEs on LDL-cholesterol. Methods: In a double-blind, randomized, parallel controlled study, 39 subjects from 21 to 55 years with moderate hypercholesterolemia without drug treatment were assigned to 2 groups and then consumed either a DS containing RYR, SCdP and ALEs or a placebo over a 16-week period. Plasma concentrations of lipids [LDL-cholesterol, total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-cholesterol), triacylglycerols (TG)] and plasma levels of vitamins C and E, total polyphenols and malondialdehyde were determined at baseline and after 4, 8, 12 and 16 weeks. Results: LDL-cholesterol and TC were reduced by, respectively, 21.4 % (95 % CI, −13.3 to −24.9 %, p < 0.001) and 14.1 % (95 % CI, −10.1 to −18.0 %, p < 0.001) at week 16 in the DS group compared with baseline. Similar results were obtained at weeks 4, 8 and 12. TG decreased by 12.2 % after 16 weeks in the DS group (95 % CI: −24.4 to −0.1 %, p < 0.05). For the vitamin E/TC ratio, a difference was observed between groups at week 16 ( p < 0.05). Other parameters were not modified. Conclusions: Daily consumption of this new DS decreased LDL-cholesterol and TC and is therefore an interesting, convenient aid in managing mild to moderate hypercholesterolemia. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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