Chemical Composition and Biological Evaluation of Physalis peruviana Root as Hepato-renal Protective Agent.
This study was designed to investigate the potential of Physalis peruviana root as a functional food with hepato-renal protective effects against fibrosis. The chemical composition of the plant root suggested the presence of alkaloids, withanolides and flavonoids. Five compounds were isolated and th...
| Publicado en: | Journal of Dietary Supplements Vol. 10; no. 1; pp. 39 - 54 |
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| Autores principales: | , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Feb2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104317946&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104317946 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19390211 2Y62 jtl: Journal of Dietary Supplements issn: 19390211 maglogo: N pubinfo: dt: Feb2013 vid: 10 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104317946 85606681 10.3109/19390211.2012.760509 NLM23419022 104317946 ppf: 39 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Chemical Composition and Biological Evaluation of Physalis peruviana Root as Hepato-renal Protective Agent. aug: au: El-Gengaihi, Souad E. Hassan, Emad E. Hamed, Manal A. Zahran, Hanan G. Mohammed, Mona A. affil: Department of Medicinal & Aromatic Plants sug: subj: Plant Roots Administration and Dosage Fibrosis Prevention and Control Plant Extracts Animal Studies Rats Kidney Diseases Liver Function Tests Histological Techniques Biological Markers Oxidative Stress Adult Male Colorimetry Descriptive Statistics Data Analysis Software Drug Toxicity Molecular Structure One-Way Analysis of Variance Spectral Analysis Adult: 19-44 years Male ab: This study was designed to investigate the potential of Physalis peruviana root as a functional food with hepato-renal protective effects against fibrosis. The chemical composition of the plant root suggested the presence of alkaloids, withanolides and flavonoids. Five compounds were isolated and their structures elucidated by different spectral analysis techniques. One compound was isolated from the roots: cuscohygrine. The biological evaluation was conducted on different animal groups; control rats, control treated with ethanolic root extract, CCl4 group, CCl4 treated with root extract, and CCl4 treated with silymarin as a standard herbal drug. The evaluation used the oxidative stress markers malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO). The liver function indices; aspartate and alanine aminotransferases (AST & ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), bilirubin, and total hepatic protein were also estimated. Kidney disorder biomarkers; creatinine, urea, and serum protein were also evaluated. The results suggested safe administration, and improvement of all the investigated parameters. The liver and kidney histopathological analysis confirmed the results. In conclusion, P. peruviana succeeded in protecting the liver and kidney against fibrosis. Further studies are needed to discern their pharmacological applications and clinical uses. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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