Supplementing Vitamins C and E to standard triple therapy for the eradication of Helicobacter pylori.
What is known and Objective: Helicobacter pylori eradication rates of currently accepted triple therapy regimens vary between geographic locations and do not exceed 70-80%. Eradication rates are much lower in locations where uncontrolled antibiotic use is common such as Turkey. In the present study,...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 37; no. 3; pp. 282 - 286 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jun2012
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104353586&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104353586 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Jun2012 vid: 37 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104353586 75254809 10.1111/j.1365-2710.2011.01286.x NLM21740452 104353586 ppf: 282 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Supplementing Vitamins C and E to standard triple therapy for the eradication of Helicobacter pylori. aug: au: Sezikli, M. Çetinkaya, Z. A. Güzelbulut, F. Yeşil, A. Coşgun, S. Kurdaş, O. Ö. affil: Department of Gastroenterology, Kocaeli Derince Research and Education Hospital, Kocaeli sug: subj: Helicobacter Infections Prevention and Control Helicobacter Infections Drug Therapy Antibiotics Therapeutic Use Dietary Supplementation Ascorbic Acid Vitamin E Drug Therapy, Combination Methods Treatment Outcomes Human Random Assignment Turkiye Amoxicillin Administration and Dosage Clarithromycin Administration and Dosage Lansoprazole Administration and Dosage Female Male Adult Middle Age Descriptive Statistics Data Analysis Software Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: What is known and Objective: Helicobacter pylori eradication rates of currently accepted triple therapy regimens vary between geographic locations and do not exceed 70-80%. Eradication rates are much lower in locations where uncontrolled antibiotic use is common such as Turkey. In the present study, we aimed to test whether supplementing vitamins C and E to standard triple therapy, including a proton pump inhibitor plus amoxicillin plus clarithromycin, increased the H. pylori eradication rate. Methods: Two hundred patients infected with H. pylori were randomized into two groups in an open-label trial. In group A, patients ( n = 160) were given standard triple therapy, including lansoprazole 30 mg BID plus amoxicillin 1000 mg BID plus clarithromycin 500 mg BID for 14 days, plus vitamin C 500 mg BID plus vitamin E 200 IU BID for 30 days. In group B, patients ( n = 40) were given standard triple therapy for 14 days. The success of H. pylori eradication was defined as a negative 14C-urea breath test result, 4-6 weeks after the completion of therapy. Comaprisons were by both intention-to-treat (ITT) and per-protocol (PP) analysis. Results and Discussion: Two hundred patients (137 women, 63 men) were analysed using ITT analysis and 195 patients completed the study. In group A, H. pylori eradication was achieved in 132 of the 160 patients (82·5%) included in ITT analysis and 132 of the 157 patients (84%) included in PP analysis. In group B, H. pylori eradication was achieved in 18 of the 40 patients (45%) included in ITT analysis and 18 of the 38 patients (47·4%) included in PP analysis. Eradication rates were significantly higher in group A than in group B ( P < 0·005). Eradication rates were not statistically significant between men and women in both groups. What is new and Conclusion: Adding vitamins C and E to standard triple therapy increases the eradication rate of H. pylori. Vitamins C and E may increase the eradication rate via increasing the effectiveness of the antibiotics by decreasing oxidative stress in the gastric mucosa and strengthening the immune system. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|