Inappropriate prescribing for the elderly-a modern epidemic?
Purpose: The elderly often use several drugs on a regular basis and are especially at risk for drug-related harm from side effects and interactions. The aim of this study was to explore the overall prevalence of and predictors for potentially inappropriate medication use among Norwegian elderly outp...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 68; no. 7; pp. 1085 - 1095 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104354928&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104354928 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Jul2012 vid: 68 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104354928 76487854 10.1007/s00228-012-1223-8 NLM22349159 104354928 ppf: 1085 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Inappropriate prescribing for the elderly-a modern epidemic? aug: au: Nyborg, Gunhild Straand, Jørund Brekke, Mette affil: Department of General Practice/Family Medicine, Institute of Health and Society, University of Oslo, Oslo Norway sug: subj: Inappropriate Prescribing Medication Errors Patient Safety Prescribing Patterns In Old Age Aged Aged, 80 and Over Confidence Intervals Cross Sectional Studies Data Analysis Software Descriptive Statistics Female Funding Source Human Logistic Regression Male Norway Odds Ratio Retrospective Design Aged: 65+ years Aged, 80 & over Female Male ab: Purpose: The elderly often use several drugs on a regular basis and are especially at risk for drug-related harm from side effects and interactions. The aim of this study was to explore the overall prevalence of and predictors for potentially inappropriate medication use among Norwegian elderly outpatients. Methods: A pharmaco-epidemiological retrospective cross-sectional survey was undertaken based on data from the Norwegian Prescription Database. Prescriptions from all doctors in Norway, dispensed by pharmacies to home-dwelling elderly ≥70 years in 2008, were included for a total of 11,491,065 prescriptions from 24,540 prescribers to 445,900 individuals (88.3% of the Norwegian population in this age group, 58.9% females). We applied a list of criteria for pharmacological inappropriateness for elderly people (the NORGEP criteria) to determine the prevalence of potentially inappropriate medications (PIMs) and applied a multiple logistic regression model to identify predictors. Results: According to our criteria, 34.8% of the study population (28.5% of the men, 39.3% of the women) was exposed to at least one PIM. Of these, 59.9% represented psychoactive substances. The odds of receiving potentially harmful prescriptions increased with the number of prescribers (OR 3.52, 99% CI 3.44-3.60 for those with ≥5 compared to those with 1 or 2 prescribers). Twenty percent were prescribed more than 10 medications; among these two-thirds had at least one PIM. Adjusted for differences in age distribution and the number of prescribers involved, women were more frequently exposed to PIMs than men, with an odds ratio of 1.60 (99% CI 1.58-1.64). Conclusions: About one-third of the elderly Norwegian population is exposed to potentially inappropriate medications, and elderly females are at particular risk. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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