The evolution of eProtocols that enable reproducible clinical research and care methods.

Unnecessary variation in clinical care and clinical research reduces our ability to determine what healthcare interventions are effective. Reducing this unnecessary variation could lead to further healthcare quality improvement and more effective clinical research. We have developed and used electro...

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Published in:Journal of Clinical Monitoring & Computing Vol. 26; no. 4; pp. 305 - 318
Main Authors: Blagev DP, Hirshberg EL, Sward K, Thompson BT, Brower R, Truwit J, Hite D, Steingrub J, Orme JF Jr, Clemmer TP, Weaver LK, Thomas F, Grissom CK, Sorenson D, Sittig DF, Wallace CJ, East TD, Warner HR, Morris AH, Blagev, Denitza P
Format: research Journal Article
Published: Springer Nature Aug2012
Online Access:View this record in EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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        atl: The evolution of eProtocols that enable reproducible clinical research and care methods.
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          Blagev DP
          Hirshberg EL
          Sward K
          Thompson BT
          Brower R
          Truwit J
          Hite D
          Steingrub J
          Orme JF Jr
          Clemmer TP
          Weaver LK
          Thomas F
          Grissom CK
          Sorenson D
          Sittig DF
          Wallace CJ
          East TD
          Warner HR
          Morris AH
          Blagev, Denitza P
        affil: Pulmonary, Division, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA
      sug:
        subj:
          Decision Support Systems, Management Administration
          Drug Therapy, Computer Assisted Methods
          Hyperglycemia Diagnosis
          Hyperglycemia Drug Therapy
          Insulin Administration and Dosage
          Internet
          Programming Languages
          Adult
          Research, Medical Methods
          Human
          Sensitivity and Specificity
          United States
          Adult: 19-44 years
      ab: Unnecessary variation in clinical care and clinical research reduces our ability to determine what healthcare interventions are effective. Reducing this unnecessary variation could lead to further healthcare quality improvement and more effective clinical research. We have developed and used electronic decision support tools (eProtocols) to reduce unnecessary variation. Our eProtocols have progressed from a locally developed mainframe computer application in one clinical site (LDS Hospital) to web-based applications available in multiple languages and used internationally. We use eProtocol-insulin as an example to illustrate this evolution. We initially developed eProtocol-insulin as a local quality improvement effort to manage stress hyperglycemia in the adult intensive care unit (ICU). We extended eProtocol-insulin use to translate our quality improvement results into usual clinical care at Intermountain Healthcare ICUs. We exported eProtocol-insulin to support research in other US and international institutions, and extended our work to the pediatric ICU. We iteratively refined eProtocol-insulin throughout these transitions, and incorporated new knowledge about managing stress hyperglycemia in the ICU. Based on our experience in the development and clinical use of eProtocols, we outline remaining challenges to eProtocol development, widespread distribution and use, and suggest a process for eProtocol development. Technical and regulatory issues, as well as standardization of protocol development, validation and maintenance, need to be addressed. Resolution of these issues should facilitate general use of eProtocols to improve patient care.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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