Determination of electrode to nerve fiber distance and nerve conduction velocity through spectral analysis of the extracellular action potentials recorded from earthworm giant fibers.
Microneurography and the use of selective microelectrodes that can resolve single-unit nerve activity have become a tool to understand the coding within the nervous system and a clinical diagnostic tool to assess peripheral neural pathologies. Central to these techniques is the use of the difference...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 50; no. 8; pp. 867 - 876 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104358301&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104358301 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Aug2012 vid: 50 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104358301 NLM22714669 2011623086 10.1007/s11517-012-0930-8 NLM22714669 104358301 ppf: 867 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Determination of electrode to nerve fiber distance and nerve conduction velocity through spectral analysis of the extracellular action potentials recorded from earthworm giant fibers. aug: au: Qiao S Odoemene O Yoshida K Qiao, Shaoyu Odoemene, Onyekachi Yoshida, Ken affil: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA sug: subj: Algorithms Electric Stimulation Equipment and Supplies Electrodes Models, Biological Nerve Fibers Physiology Neural Conduction Physiology Invertebrates Physiology Animals Computer Simulation Interstitial Fluid Physiology ab: Microneurography and the use of selective microelectrodes that can resolve single-unit nerve activity have become a tool to understand the coding within the nervous system and a clinical diagnostic tool to assess peripheral neural pathologies. Central to these techniques is the use of the differences in the shape of the extracellular action potential (AP) waveform to identify and discriminate units from one another. Theoretical modeling of the origins of these shape differences has shown that the position of the nerve fiber relative to the electrode and the conduction velocity of the unit contribute to these differences giving rise to the hypothesis that more information about the fiber and its relationship to the electrode could be extracted given further analysis of the AP waveform. This paper addresses this question by exploring the electrical coupling between the electrode and nerve fiber. Idealized models and the literature indicate that two parameters, the electrode-fiber distance and the unit conduction velocity, contribute to the amplitude of the extracellular AP detected by the electrode, which confounds the quantification of coupling using the spike amplitude alone. To resolve this, we develop a method that enables differential quantification of these two parameters using spectral analysis of the single-unit AP waveform and demonstrate that the two parameters could be effectively decoupled in an in vitro earthworm model. The method could open the way forward toward micro-scale in situ monitoring of the interaction of nerve fiber and neural interface. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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