Assessment of ropinirole as a reinforcer in rhesus monkeys.
BACKGROUND: Ropinirole, a D(2)/D(3)/5-HT(1A) agonist, is used for the treatment of Parkinson's disease and restless leg syndrome, and is currently being evaluated as a treatment for cocaine dependence. However, there is little information available on ropinirole's reinforcing effects. METHODS: The c...
| Publicado en: | Drug & Alcohol Dependence Vol. 125; no. 1/2; pp. 173 - 178 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Sep2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104361691&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104361691 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03768716 3S6 jtl: Drug & Alcohol Dependence issn: 03768716 maglogo: N pubinfo: dt: Sep2012 vid: 125 iid: 1/2 pid: 1004 pub: Elsevier B.V. artinfo: ui: 104361691 2011651840 10.1016/j.drugalcdep.2012.04.001 NLM22546848 104361691 ppf: 173 ppct: 5 formats: tig: atl: Assessment of ropinirole as a reinforcer in rhesus monkeys. aug: au: Freeman KB Heal DJ McCreary AC Woolverton WL affil: Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, The University of Mississippi Medical Center, Jackson, MS 39216, USA. sug: subj: Conditioning (Psychology) Drug Effects Dopamine Agonists Pharmacodynamics Indoles Pharmacodynamics Reinforcement (Psychology) Animal Studies Cocaine Pharmacodynamics Data Analysis, Statistical Dopamine Uptake Inhibitors Pharmacodynamics Dose-Response Relationship, Drug Injections, Intravenous Male Primates Receptors, Cell Surface Self Administration Male ab: BACKGROUND: Ropinirole, a D(2)/D(3)/5-HT(1A) agonist, is used for the treatment of Parkinson's disease and restless leg syndrome, and is currently being evaluated as a treatment for cocaine dependence. However, there is little information available on ropinirole's reinforcing effects. METHODS: The current study tested ropinirole in monkeys (n=7) trained to self administer cocaine on a fixed-ratio 25 (FR 25) schedule of reinforcement to determine if it would function as a reinforcer. In addition, a behavioral economics approach was used in four monkeys to compare the reinforcing effectiveness of ropinirole to cocaine. RESULTS: Cocaine (0.01-0.3mg/kg/injection) functioned as a reinforcer in all monkeys under the FR 25 schedule, and ropinirole (0.01-0.1mg/kg/injection) functioned as a reinforcer in all but one. Furthermore, cocaine was a more effective reinforcer than ropinirole as indexed by demand functions. CONCLUSION: The current data indicate that ropinirole has reinforcing effects in monkeys, although its effectiveness as a reinforcer is relatively weak. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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