Higher frequency of cagA EPIYA-C phosphorylation sites in H. pylori strains from first-degree relatives of gastric cancer patients.
Background: To evaluate the prevalence of more virulent H. pylori genotypes in relatives of gastric cancer patients and in patients without family histories of gastric cancer.Methods: We evaluated prospectively the prevalence of the infection by more virulent H. pylori strains in 60 relatives of gas...
| Publicado en: | BMC Gastroenterology Vol. 12; no. 1; pp. 107 - 108 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104371878&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104371878 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1471230X 1CHO jtl: BMC Gastroenterology issn: 1471230X maglogo: N pubinfo: dt: 2012 vid: 12 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 104371878 NLM22891666 2011700748 10.1186/1471-230X-12-107 NLM22891666 PMC3462145 104371878 ppf: 107 ppct: 1 formats: tig: atl: Higher frequency of cagA EPIYA-C phosphorylation sites in H. pylori strains from first-degree relatives of gastric cancer patients. aug: au: Queiroz, Dulciene Mm Silva, Cícero Ism Goncalves, Maria Hrb Braga-Neto, Manuel B Fialho, Andréa Bc Fialho, André Mn Rocha, Gifone A Rocha, Andreia Mc Batista, Sérgio A Guerrant, Richard L Lima, Aldo Am Braga, Lucia Lbc Queiroz, Dulciene M M Silva, Cícero I S M Goncalves, Maria H R B Fialho, Andréa B C Fialho, André M N Rocha, Andreia M C Lima, Aldo A M Braga, Lucia L B C affil: Laboratory of Research in Bacteriology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil sug: subj: Antigens, Bacterial Metabolism Bacterial Proteins Metabolism Carcinoma Microbiology Helicobacter Infections Microbiology Helicobacter Pylori Stomach Neoplasms Microbiology Adult Amino Acids Antigens, Bacterial Bacterial Proteins Nucleotides Carcinoma Epidemiology Carcinoma Metabolism Carcinoma Pathology Family Female Helicobacter Infections Epidemiology Helicobacter Infections Pathology Human Male Middle Age Documentation Metabolism Prevalence Prospective Studies Sequence Analysis Stomach Neoplasms Epidemiology Stomach Neoplasms Metabolism Stomach Neoplasms Pathology Urease Analysis Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background: To evaluate the prevalence of more virulent H. pylori genotypes in relatives of gastric cancer patients and in patients without family histories of gastric cancer.Methods: We evaluated prospectively the prevalence of the infection by more virulent H. pylori strains in 60 relatives of gastric cancer patients comparing the results with those obtained from 49 patients without family histories of gastric cancer. H. pylori status was determined by the urease test, histology and presence of H. pylori ureA. The cytotoxin associated gene (cagA), the cagA-EPIYA and vacuolating cytotoxin gene (vacA) were typed by PCR and the cagA EPIYA typing was confirmed by sequencing.Results: The gastric cancer relatives were significant and independently more frequently colonized by H. pylori strains with higher numbers of CagA-EPIYA-C segments (OR = 4.23, 95%CI = 1.53-11.69) and with the most virulent s1m1 vacA genotype (OR = 2.80, 95%CI = 1.04-7.51). Higher numbers of EPIYA-C segments were associated with increased gastric corpus inflammation, foveolar hyperplasia and atrophy. Infection by s1m1 vacA genotype was associated with increased antral and corpus gastritis.Conclusions: We demonstrated that relatives of gastric cancer patients are more frequently colonized by the most virulent H. pylori cagA and vacA genotypes, which may contribute to increase the risk of gastric cancer. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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