Evaluation of MR imaging with T1 and T2* mapping for the determination of hepatic iron overload.
Objectives: To evaluate MRI using T1 and T2* mapping sequences in patients with suspected hepatic iron overload (HIO).Methods: Twenty-five consecutive patients with clinically suspected HIO were retrospectively studied. All underwent MRI and liver biopsy. For the quantification of liver T2* values w...
| Publicado en: | European Radiology Vol. 22; no. 11; pp. 2478 - 2487 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Nov2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104375013&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104375013 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Nov2012 vid: 22 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104375013 82504648 NLM22645044 2011718103 10.1007/s00330-012-2506-2 NLM22645044 104375013 ppf: 2478 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Evaluation of MR imaging with T1 and T2* mapping for the determination of hepatic iron overload. aug: au: Henninger B Kremser C Rauch S Eder R Zoller H Finkenstedt A Michaely HJ Schocke M Henninger, B Kremser, C Rauch, S Eder, R Zoller, H Finkenstedt, A Michaely, H J Schocke, M affil: Department of Radiology, Innsbruck Medical University, Anichstraße 35, 6020, Innsbruck, Austria sug: subj: Image Processing, Computer Assisted Methods Iron Overload Diagnosis Liver Pathology Magnetic Resonance Imaging Methods Adult Aged Biopsy Fatty Liver Diagnosis Female Histocompatibility Antigens Human Male Membrane Proteins Middle Age Polymorphism, Genetic ROC Curve Reproducibility of Results Retrospective Design Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: To evaluate MRI using T1 and T2* mapping sequences in patients with suspected hepatic iron overload (HIO).Methods: Twenty-five consecutive patients with clinically suspected HIO were retrospectively studied. All underwent MRI and liver biopsy. For the quantification of liver T2* values we used a fat-saturated multi-echo gradient echo sequence with 12 echoes (TR = 200 ms, TE = 0.99 ms + n × 1.41 ms, flip angle 20°). T1 values were obtained using a fast T1 mapping sequence based on an inversion recovery snapshot FLASH sequence. Parameter maps were analysed using regions of interest.Results: ROC analysis calculated cut-off points at 10.07 ms and 15.47 ms for T2* in the determination of HIO with accuracy 88 %/88 %, sensitivity 84 %/89.5 % and specificity 100 %/83 %. MRI correctly classified 20 patients (80 %). All patients with HIO only had decreased T1 and T2* relaxation times. There was a significant difference in T1 between patients with HIO only and patients with HIO and steatohepatitis (P = 0.018).Conclusions: MRI-based T2* relaxation diagnoses HIO very accurately, even at low iron concentrations. Important additional information may be obtained by the combination of T1 and T2* mapping. It is a rapid, non-invasive, accurate and reproducible technique for validating the evidence of even low hepatic iron concentrations.Key Points: • Hepatic iron overload causes fibrosis, cirrhosis and increases hepatocellular carcinoma risk. • MRI detects iron because of the field heterogeneity generated by haemosiderin. • T2* relaxation is very accurate in diagnosing hepatic iron overload. • Additional information may be obtained by T1 and T2* mapping. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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