Detection of non-alcoholic steatohepatitis in patients with morbid obesity before bariatric surgery: preliminary evaluation with acoustic radiation force impulse imaging.
Objective: To investigate the utility of acoustic radiation force impulse (ARFI) imaging, with the determination of shear wave velocity (SWV), to differentiate non-alcoholic fatty liver disease (NAFLD) from non-alcoholic steatohepatitis (NASH) in patients with morbid obesity before bariatric surgery...
| Publicado en: | European Radiology Vol. 22; no. 11; pp. 2525 - 2533 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Nov2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104375014&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104375014 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Nov2012 vid: 22 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104375014 82504647 NLM22648049 2011718104 10.1007/s00330-012-2505-3 NLM22648049 104375014 ppf: 2525 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Detection of non-alcoholic steatohepatitis in patients with morbid obesity before bariatric surgery: preliminary evaluation with acoustic radiation force impulse imaging. aug: au: Guzmán-Aroca F Frutos-Bernal MD Bas A Luján-Mompeán JA Reus M de Dios Berná-Serna J Parrilla P Guzmán-Aroca, F Frutos-Bernal, M D Bas, A Luján-Mompeán, J A Reus, M Berná-Serna, Juan de Dios Parrilla, P affil: Department of of Radiology, Virgen de la Arrixaca University Hospital, 30120, El Palmar, Murcia, Spain sug: subj: Bariatric Surgery Methods Fatty Liver Complications Fatty Liver Diagnosis Obesity, Morbid Complications Ultrasonography Methods Acoustics Adult Biopsy Female Human Inflammation Liver Physiopathology Liver Ultrasonography Male Middle Age Prospective Studies ROC Curve Weights and Measures Reproducibility of Results Biomechanics Stress, Mechanical Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objective: To investigate the utility of acoustic radiation force impulse (ARFI) imaging, with the determination of shear wave velocity (SWV), to differentiate non-alcoholic fatty liver disease (NAFLD) from non-alcoholic steatohepatitis (NASH) in patients with morbid obesity before bariatric surgery.Methods: Thirty-two patients with morbid obesity were evaluated with ARFI and conventional ultrasound before bariatric surgery. The ARFI and ultrasound results were compared with liver biopsy findings, which is the reference standard. The patients were classed according to their histological findings into three groups: group A, simple steatosis; group B, inflammation; and group C, fibrosis.Results: The median SWV was 1.57 ± 0.79 m/s. Hepatic alterations were observed in the histopathological findings for all the patients in the study (100 %), with the results of the laboratory tests proving normal. Differences in SWV were also observed between groups A, B and C: 1.34 ± 0.90 m/s, 1.55 ± 0.79 m/s and 1.86 ± 0.75 m/s (P < 0.001), respectively. The Az for differentiating NAFLD from NASH or fibrosis was 0.899 (optimal cut-off value 1.3 m/s; sensitivity 85 %; specificity 83.3 %).Conclusion: The ARFI technique is a useful diagnostic tool for differentiating NAFLD from NASH in asymptomatic patients with morbid obesity.Key Points: • Acoustic radiation force impulse imaging provides ultrasonic shear wave velocity measurements. • SWV measurements were higher in patients with inflammation or fibrosis than NAFLD. • ARFI differentiates NAFLD from NASH in patients with morbid obesity. • Results suggest that ARFI can detect NASH in asymptomatic morbidly obese patients. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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