PET/CT in lung cancer: Influence of contrast medium on quantitative and clinical assessment.
Objectives: To evaluate the influence of intravenous contrast medium and different contrast medium phases on attenuation correction, PET image quality and clinical staging in combined PET/CT in patients with a suspicion of lung cancer.Methods: Sixty patients with a suspicion of lung cancer were pros...
| Publicado en: | European Radiology Vol. 22; no. 11; pp. 2458 - 2465 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Nov2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104375027&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104375027 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Nov2012 vid: 22 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104375027 82504636 NLM22661058 2011718117 10.1007/s00330-012-2515-1 NLM22661058 104375027 ppf: 2458 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: PET/CT in lung cancer: Influence of contrast medium on quantitative and clinical assessment. aug: au: Behrendt FF Temur Y Verburg FA Palmowski M Krohn T Pietsch H Kuhl CK Mottaghy FM Behrendt, Florian F Temur, Yavuz Verburg, Frederik A Palmowski, Moritz Krohn, Thomas Pietsch, Hubertus Kuhl, Christiane K Mottaghy, Felix M affil: Department of Nuclear Medicine, University Hospital, RWTH-Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany sug: subj: Contrast Media Pharmacodynamics Lung Neoplasms Diagnosis Lung Neoplasms Radiography Tomography, Emission-Computed Methods Tomography, X-Ray Computed Methods Adult Aged Aged, 80 and Over Female Human Image Processing, Computer Assisted Male Oncology Methods Middle Age Radiographic Image Interpretation, Computer-Assisted Reproducibility of Results Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objectives: To evaluate the influence of intravenous contrast medium and different contrast medium phases on attenuation correction, PET image quality and clinical staging in combined PET/CT in patients with a suspicion of lung cancer.Methods: Sixty patients with a suspicion of lung cancer were prospectively enrolled for combined (18)F-FDG-PET/CT examination. PET images were reconstructed with non-enhanced and arterial and venous phase contrast CT. Maximum and mean standardised uptake values (SUVmax and SUVmean) and contrast enhancement (HU) were determined in the subclavian vein, ascending aorta, abdominal aorta, inferior vena cava, portal vein, liver and kidney and lung tumour. PET data were evaluated visually for clinical staging and image quality.Results: SUVmax was significantly increased between contrast and non-contrast PET/CT at all anatomic sites (all P < 0.001). SUVmax was significantly increased for arterial PET/CT compared to venous PET/CT in the arteries (all P < 0.001). Venous PET/CT resulted in significantly higher SUVmax values compared to arterial PET/CT in the parenchymatous organs (all P < 0.05). Visual clinical evaluation of malignant lesions showed no differences between contrast and non-contrast PET/CT (P = 1.0).Conclusions: Contrast enhanced CT is suitable for attenuation correction in combined PET/CT in lung cancer; it affects neither the clinical assessment nor image quality of the PET images.Key Points: • Positron emission tomography combined with computed tomography is now a mainstream investigation • There has been debate about whether CT contrast agents affect PET results • Contrast-enhanced CT is satisfactory for attenuation correction in lung cancer PET/CT • Multiphase CT does not affect PET; additional unenhanced CT is unnecessary • For quantitative follow-up PET analysis, an identical PET/CT protocol is required. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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