Acute stroke: a comparison of different CT perfusion algorithms and validation of ischaemic lesions by follow-up imaging.
Objectives: To compare ischaemic lesions predicted by different CT perfusion (CTP) post-processing techniques and validate CTP lesions compared with final lesion size in stroke patients.Methods: Fifty patients underwent CT, CTP and CT angiography. Quantitative values and colour maps were calculated...
| Publicado en: | European Radiology Vol. 22; no. 12; pp. 2559 - 2568 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104378899&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104378899 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Dec2012 vid: 22 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104378899 83006754 NLM22717727 2011737143 10.1007/s00330-012-2529-8 NLM22717727 104378899 ppf: 2559 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Acute stroke: a comparison of different CT perfusion algorithms and validation of ischaemic lesions by follow-up imaging. aug: au: Abels B Villablanca JP Tomandl BF Uder M Lell MM Abels, Benjamin Villablanca, J Pablo Tomandl, Bernd F Uder, Michael Lell, Michael M affil: Institute of Radiology, University Hospital Erlangen, Erlangen, Germany sug: subj: Algorithms Cerebral Ischemia Radiography Stroke Radiography Tomography, X-Ray Computed Methods Aged Cerebral Ischemia Drug Therapy Coronary Angiography Female Human Regression Magnetic Resonance Imaging Male Predictive Value of Tests Radiographic Image Interpretation, Computer-Assisted Retrospective Design Software Nonparametric Statistics Stroke Drug Therapy Thrombolytic Therapy Aged: 65+ years Female Male ab: Objectives: To compare ischaemic lesions predicted by different CT perfusion (CTP) post-processing techniques and validate CTP lesions compared with final lesion size in stroke patients.Methods: Fifty patients underwent CT, CTP and CT angiography. Quantitative values and colour maps were calculated using least mean square deconvolution (LMSD), maximum slope (MS) and conventional singular value decomposition deconvolution (SVDD) algorithms. Quantitative results, core/penumbra lesion sizes and Alberta Stroke Programme Early CT Score (ASPECTS) were compared among the algorithms; lesion sizes and ASPECTS were compared with final lesions on follow-up MRI + MRA or CT + CTA as a reference standard, accounting for recanalisation status.Results: Differences in quantitative values and lesion sizes were statistically significant, but therapeutic decisions based on ASPECTS and core/penumbra ratios would have been the same in all cases. CTP lesion sizes were highly predictive of final infarct size: Coefficients of determination (R (2)) for CTP versus follow-up lesion sizes in the recanalisation group were 0.87, 0.82 and 0.61 (P < 0.001) for LMSD, MS and SVDD, respectively, and 0.88, 0.87 and 0.76 (P < 0.001), respectively, in the non-recanalisation group.Conclusions: Lesions on CT perfusion are highly predictive of final infarct. Different CTP post-processing algorithms usually lead to the same clinical decision, but for assessing lesion size, LMSD and MS appear superior to SVDD.Key Points: Following an acute stroke, CT perfusion imaging can help predict lesion evolution. Delay-insensitive deconvolution and maximum slope approach are superior to delay-sensitive deconvolution regarding accuracy. Different CT perfusion post-processing algorithms usually lead to the same clinical decision. CT perfusion offers new insights into the evolution of stroke. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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