A comparison of MR elastography and 31P MR spectroscopy with histological staging of liver fibrosis.
Objectives: Conventional imaging techniques are insensitive to liver fibrosis. This study assesses the diagnostic accuracy of MR elastography (MRE) stiffness values and the ratio of phosphomonoesters (PME)/phosphodiesters (PDE) measured using (31)P spectroscopy against histological fibrosis staging....
| Publicado en: | European Radiology Vol. 22; no. 12; pp. 2790 - 2798 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104378906&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104378906 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Dec2012 vid: 22 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104378906 83006750 NLM22752441 2011737147 10.1007/s00330-012-2527-x NLM22752441 104378906 ppf: 2790 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A comparison of MR elastography and 31P MR spectroscopy with histological staging of liver fibrosis. aug: au: Godfrey EM Patterson AJ Priest AN Davies SE Joubert I Krishnan AS Griffin N Shaw AS Alexander GJ Allison ME Griffiths WJ Gimson AE Lomas DJ Godfrey, Edmund M Patterson, Andrew J Priest, Andrew N Davies, Susan E Joubert, Ilse Krishnan, Anant S Griffin, Nyree affil: St James' Hospital, Beckett Street, Leeds, LS9 7TF, UK sug: subj: Ultrasonography Methods Liver Cirrhosis Pathology Magnetic Resonance Spectroscopy Methods Biopsy Female Human Male Middle Age Prospective Studies ROC Curve Middle Aged: 45-64 years Female Male ab: Objectives: Conventional imaging techniques are insensitive to liver fibrosis. This study assesses the diagnostic accuracy of MR elastography (MRE) stiffness values and the ratio of phosphomonoesters (PME)/phosphodiesters (PDE) measured using (31)P spectroscopy against histological fibrosis staging.Methods: The local research ethics committee approved this prospective, blinded study. A total of 77 consecutive patients (55 male, aged 49 ± 11.5 years) with a clinical suspicion of liver fibrosis underwent an MR examination with a liver biopsy later the same day. Patients underwent MRE and (31)P spectroscopy on a 1.5 T whole body system. The liver biopsies were staged using an Ishak score for chronic hepatitis or a modified NAS fibrosis score for fatty liver disease.Results: MRE increased with and was positively associated with fibrosis stage (Spearman's rank = 0.622, P < 0.001). PME/PDE was not associated with fibrosis stage (Spearman's rank = -0.041, p = 0.741). Area under receiver operating curves for MRE stiffness values were high (range 0.75-0.97). The diagnostic utility of PME/PDE was no better than chance (range 0.44-0.58).Conclusions: MRE-estimated liver stiffness increases with fibrosis stage and is able to dichotomise fibrosis stage groupings. We did not find a relationship between (31)P MR spectroscopy and fibrosis stage.Key Points: Magnetic resonance elastography (MRE) and MR spectroscopy can both assess the liver. MRE is superior to ( 31 ) P MR spectroscopy in staging hepatic fibrosis. MRE is able to dichotomise liver fibrosis stage groupings. Gradient-echo MRE may be problematic in genetic haemochromatosis. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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