Cross-validation of input functions obtained by H₂ 15O PET imaging of rat heart and a blood flow-through detector.
Purpose: Positron emission tomography (PET) with ¹⁵O-labeled water (H₂ ¹⁵O) facilitates the visualization and quantification of blood flow in clinical investigations and also in small animals. The quantification of blood flow requires an input function, which is generally obtained by measuring radio...
| Publicado en: | Molecular Imaging & Biology Vol. 14; no. 4; pp. 509 - 517 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104382886&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104382886 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Aug2012 vid: 14 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104382886 104382886 NLM21811861 2011753428 10.1007/s11307-011-0511-5 NLM21811861 104382886 ppf: 509 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Cross-validation of input functions obtained by H₂ 15O PET imaging of rat heart and a blood flow-through detector. aug: au: Kudomi N Sipilä H Autio A Oikonen V Liljenbäck H Tarkia M Laivola J Johansson J Teräs M Roivainen A Kudomi, Nobuyuki Sipilä, Hannu Autio, Anu Oikonen, Vesa Liljenbäck, Heidi Tarkia, Miikka Laivola, Jarno Johansson, Jarkko Teräs, Mika Roivainen, Anne affil: Turku PET Centre, University of Turku and Turku University Hospital, Finland sug: subj: Coronary Circulation Physiology Heart Radiography Tomography, Emission-Computed Equipment and Supplies Tomography, Emission-Computed Methods Water Diagnostic Use Animal Studies Brain Radiography Cerebrovascular Circulation Physiology Linear Regression Male Radioisotopes Rats Reproducibility of Results Male ab: Purpose: Positron emission tomography (PET) with ¹⁵O-labeled water (H₂ ¹⁵O) facilitates the visualization and quantification of blood flow in clinical investigations and also in small animals. The quantification of blood flow requires an input function, which is generally obtained by measuring radioactivity in arterial blood withdrawn during PET scanning. However, this approach is not always feasible, because abundant blood sampling may affect the physiological process being measured. The purpose of the present study was to develop and cross-validate two methods, namely, a blood- and an image-based method for obtaining the input function for blood flow studies from rat H₂ ¹⁵O PET.Methods: The study material consisted of two separate groups of rats. Group 1 rats were imaged twice by a high-resolution research tomograph PET camera at resting condition for a test-retest study (n = 4), and group 2 rats were imaged with and without adenosine infusion for a rest-stress study (n = 4). In group 1, radioactivity concentration in arterial blood was measured with a new flow-through detector during imaging and a blood-based input function was obtained. The image-based input function was estimated using time-activity curves from the left ventricle and myocardial regions. To validate the two input function methods, myocardial blood flow (MBF) and cerebral blood flow (CBF) were computed, and the methods were tested for reproducibility (test-retest study) and changes (rest-stress study).Results: The blood- and image-based input functions were similar, and the corresponding CBF values differed only by -6.9 ± 8.1%. In the test-retest study, both MBF and CBF showed good reproducibility, and in the rest-stress study, adenosine significantly increased both MBF (P = 0.035) and CBF (P = 0.029), compared with the resting condition.Conclusion: It is possible both to measure the input function from rat arteria femoralis during H₂ ¹⁵O PET imaging and to estimate the input function from rat H₂ ¹⁵O PET images, thereby facilitating the assessment of blood flow in organs visible in PET images. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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