A multimode optical imaging system for preclinical applications in vivo: technology development, multiscale imaging, and chemotherapy assessment.
Purpose: Several established optical imaging approaches have been applied, usually in isolation, to preclinical studies; however, truly useful in vivo imaging may require a simultaneous combination of imaging modalities to examine dynamic characteristics of cells and tissues. We developed a new mult...
| Publicado en: | Molecular Imaging & Biology Vol. 14; no. 4; pp. 431 - 443 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104382891&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104382891 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Aug2012 vid: 14 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104382891 NLM21874388 2011753434 10.1007/s11307-011-0517-z NLM21874388 PMC3487699 104382891 ppf: 431 ppct: 12 formats: fmt: @attributes: type: P tig: atl: A multimode optical imaging system for preclinical applications in vivo: technology development, multiscale imaging, and chemotherapy assessment. aug: au: Hwang JY Wachsmann-Hogiu S Ramanujan VK Ljubimova J Gross Z Gray HB Medina-Kauwe LK Farkas DL Hwang, Jae Youn Wachsmann-Hogiu, Sebastian Ramanujan, V Krishnan Ljubimova, Julia Gross, Zeev Gray, Harry B Medina-Kauwe, Lali K Farkas, Daniel L affil: Minimally Invasive Surgical Technologies Institute and Department of Surgery, Cedars-Sinai Medical Center, 8700 Beverly Blvd. D6061, Los Angeles, CA 90048, USA sug: subj: Antineoplastic Agents Therapeutic Use Equipment and Supplies Molecular Imaging Methods Neoplasms Diagnosis Neoplasms Drug Therapy Xenografts Animal Studies Cells Human Immunity Luminescent Measurements Mice Nanotechnology Pilot Studies Rats Spectrometry, Fluorescence ab: Purpose: Several established optical imaging approaches have been applied, usually in isolation, to preclinical studies; however, truly useful in vivo imaging may require a simultaneous combination of imaging modalities to examine dynamic characteristics of cells and tissues. We developed a new multimode optical imaging system designed to be application-versatile, yielding high sensitivity, and specificity molecular imaging.Procedures: We integrated several optical imaging technologies, including fluorescence intensity, spectral, lifetime, intravital confocal, two-photon excitation, and bioluminescence, into a single system that enables functional multiscale imaging in animal models.Results: The approach offers a comprehensive imaging platform for kinetic, quantitative, and environmental analysis of highly relevant information, with micro-to-macroscopic resolution. Applied to small animals in vivo, this provides superior monitoring of processes of interest, represented here by chemo-/nanoconstruct therapy assessment.Conclusions: This new system is versatile and can be optimized for various applications, of which cancer detection and targeted treatment are emphasized here. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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